F-box only protein 24 is a protein that in humans is encoded by the FBXO24 gene .[ 5] [ 6] [ 7]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine -rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates two transcript variants.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000106336 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089984 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins" . Curr Biol . 9 (20): 1177–9. Bibcode :1999CBio....9.1177C . doi :10.1016/S0960-9822(00)80020-2 . PMID 10531035 . S2CID 7467493 .
^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins" . Curr Biol . 9 (20): 1180–2. Bibcode :1999CBio....9.1180W . doi :10.1016/S0960-9822(00)80021-4 . PMID 10531037 . S2CID 14341845 .
^ a b "Entrez Gene: FBXO24 F-box protein 24" .
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