F-box protein 16

F-box protein 16 is a protein that in humans is encoded by the FBXO16 gene.

FBXO16
Identifiers
Aliases	FBXO16, FBX16, F-box protein 16
External IDs	OMIM: 608519; MGI: 1354706; HomoloGene: 9273; GeneCards: FBXO16; OMA:FBXO16 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.1 Start 28,348,287 bp End 28,490,278 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D1 Start 65,504,067 bp End 65,561,422 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary testicle Brodmann area 9 right hemisphere of cerebellum nucleus accumbens right frontal lobe islet of Langerhans gonad prefrontal cortex right uterine tube Top expressed in zygote tail of embryo olfactory epithelium morula embryo neural tube genital tubercle ganglionic eminence embryo ventricular zone More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 157574 50759 Ensembl ENSG00000214050 ENSMUSG00000034532 UniProt Q8IX29 Q9QZM9 RefSeq (mRNA) NM_172366 NM_001258211 NM_015795 NM_001360381 NM_001360383 RefSeq (protein) NP_001245140 NP_758954 NP_056610 NP_001347310 NP_001347312 Location (UCSC) Chr 8: 28.35 – 28.49 Mb Chr 14: 65.5 – 65.56 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Cheng H, Ma Y, Ni X, Jiang M, Guo L, Jin W, Xu W, Cao G, Ji C, Yin K, Gu S, Ma Y, Xie Y, Mao Y (2002). "cDNA cloning and expression analysis of a novel human F-box only protein". Mol. Cells. 14 (1): 56–9. PMID 12243353.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.