Etoetonitazene

Etoetonitazene
Identifiers
	IUPAC name 2-[2-[[4-(2-ethoxyethoxy)phenyl]methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine;
CAS Number	806642-21-7;
PubChem CID	162623504;
UNII	7UM76V2RG4;
Chemical and physical data
Formula	C24H32N4O4
Molar mass	440.544 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OCCOCC;
	InChI InChI=1S/C24H32N4O4/c1-4-26(5-2)13-14-27-23-12-9-20(28(29)30)18-22(23)25-24(27)17-19-7-10-21(11-8-19)32-16-15-31-6-3/h7-12,18H,4-6,13-17H2,1-3H3; Key:NWEAJFXJKVCITM-UHFFFAOYSA-N;

Etoetonitazene is a benzimidazole derivative with opioid effects, first developed in the 1950s as part of the research that led to better-known compounds such as etonitazene. It is an analogue of etonitazene where the ethoxy sidechain has been extended to ethoxyethoxy. It is less potent than other benzimidazole class opioids, but is still a potent mu opioid receptor agonist with around 50x the potency of morphine, and has been sold as a designer drug since around 2022.^[1]^[2]

References

^ "A review of the evidence on the use and harms of 2-benzyl benzimidazole ('nitazene') and piperidine benzimidazolone ('brorphine-like') opioids" (PDF). UK: Advisory Council on the Misuse of Drugs. July 2022.
^ Hasegawa K, Minakata K, Suzuki M, Suzuki O (July 2022). "Non-fentanyl-derived synthetic opioids emerging during recent years". Forensic Toxicology. 40 (2): 234–243. doi:10.1007/s11419-022-00624-y. PMC 9052731. PMID 36454418.

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[1] "A review of the evidence on the use and harms of 2-benzyl benzimidazole ('nitazene') and piperidine benzimidazolone ('brorphine-like') opioids" (PDF). UK: Advisory Council on the Misuse of Drugs. July 2022.

[pmid36454418-2] Hasegawa K, Minakata K, Suzuki M, Suzuki O (July 2022). "Non-fentanyl-derived synthetic opioids emerging during recent years". Forensic Toxicology. 40 (2): 234–243. doi:10.1007/s11419-022-00624-y. PMC 9052731. PMID 36454418.

[1]

[2]

Identifiers

IUPAC name 2-[2-[[4-(2-ethoxyethoxy)phenyl]methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine
CAS Number	806642-21-7
PubChem CID	162623504
UNII	7UM76V2RG4
Chemical and physical data
Formula	C₂₄H₃₂N₄O₄
Molar mass	440.544 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CC)CCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OCCOCC
InChI InChI=1S/C24H32N4O4/c1-4-26(5-2)13-14-27-23-12-9-20(28(29)30)18-22(23)25-24(27)17-19-7-10-21(11-8-19)32-16-15-31-6-3/h7-12,18H,4-6,13-17H2,1-3H3 Key:NWEAJFXJKVCITM-UHFFFAOYSA-N

Etoetonitazene

See also

References