ERG11 or Sterol 14-demethylase is a fungal cytochrome P450 enzyme originally from Saccharomyces cerevisiae, belongs to family CYP51, with the CYP Symbol CYP51F1.[1] ERG11 catalyzes the C14-demethylation of lanosterol to 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first step of biosynthesis of the zymosterol, zymosterol will be further converted into Ergosterol.[2]
| Sterol 14-demethylase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | ERG11 | ||||||
| Alt. symbols | CYP51F1 | ||||||
| Entrez | 856398 | ||||||
| HomoloGene | 55488 | ||||||
| RefSeq (mRNA) | NM_001179137 | ||||||
| RefSeq (Prot) | NP_011871 | ||||||
| UniProt | P10614 | ||||||
| Other data | |||||||
| EC number | 1.14.14.154 | ||||||
| Chromosome | VIII: 0.12 - 0.12 Mb | ||||||
| |||||||
References
edit- ^ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. (October 2003). "Global analysis of protein expression in yeast". Nature. 425 (6959): 737–41. Bibcode:2003Natur.425..737G. doi:10.1038/nature02046. PMID 14562106. S2CID 4344864.
- ^ Mo C, Bard M (September 2005). "Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex". Journal of Lipid Research. 46 (9): 1991–8. doi:10.1194/jlr.M500153-JLR200. PMID 15995173.
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