ELP3

Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene. ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex. In mammals, ELP3 is important for paternal DNA demethylation after fertilization. ELP3 is potentially involved in cellular redox homeostasis by mediating the acetylation of glucose-6-phosphate dehydrogenase. Besides, ELP3 may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

ELP3
Identifiers
Aliases	ELP3, KAT9, elongator acetyltransferase complex subunit 3
External IDs	OMIM: 612722; MGI: 1921445; HomoloGene: 7105; GeneCards: ELP3; OMA:ELP3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.1 Start 28,089,673 bp End 28,191,156 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D1 Start 65,767,898 bp End 65,830,524 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus endometrium Achilles tendon epithelium of colon germinal epithelium internal globus pallidus primary visual cortex seminal vesicula Top expressed in primitive streak ventricular zone somite epiblast dentate gyrus of hippocampal formation granule cell muscle of thigh maxillary prominence calvaria mandibular prominence neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity RNA polymerase II complex binding iron-sulfur cluster binding H4 histone acetyltransferase activity H3 histone acetyltransferase activity metal ion binding histone acetyltransferase activity phosphorylase kinase regulator activity protein binding catalytic activity acyltransferase activity acetyltransferase activity Cellular component cytoplasm elongator holoenzyme complex nucleolus histone acetyltransferase complex transcription elongation factor complex nucleus Biological process regulation of transcription, DNA-templated positive regulation of cell migration regulation of transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter neuron migration transcription, DNA-templated nervous system development central nervous system development histone H3 acetylation histone H4 acetylation regulation of protein kinase activity tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation histone acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55140 74195 Ensembl ENSG00000134014 ENSMUSG00000022031 UniProt Q9H9T3 Q9CZX0 RefSeq (mRNA) NM_001284220 NM_001284222 NM_001284224 NM_001284225 NM_001284226 NM_018091 NM_001253812 NM_028811 RefSeq (protein) NP_001271149 NP_001271151 NP_001271153 NP_001271154 NP_001271155 NP_060561 NP_001240741 NP_083087 Location (UCSC) Chr 8: 28.09 – 28.19 Mb Chr 14: 65.77 – 65.83 Mb PubMed search
Wikidata
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Further reading

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• Ninomiya Y, Okada M, Kotomura N, et al. (1996). "Genomic organization and isoforms of the mouse ELP gene". J. Biochem. 118 (2): 380–9. doi:10.1093/oxfordjournals.jbchem.a124918. PMID 8543574.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
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• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. Bibcode:2002PNAS...99.1241K. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
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• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Han Q, Hou X, Su D, et al. (2007). "hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells". Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 453–61. doi:10.1111/j.1745-7270.2007.00293.x. PMID 17558451.