dnaN is the gene that codes for the DNA clamp (also known as β sliding clamp) of DNA polymerase III in prokaryotes.[2][3] The β clamp physically locks Pol III onto a DNA strand during replication to help increase its processivity.[4] The eukaryotic equivalent to the β clamp is PCNA.
| DNA polymerase III subunit beta | |||||||
|---|---|---|---|---|---|---|---|
 | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | dnaN | ||||||
| Entrez | 948218 | ||||||
| PDB | 1MMI | ||||||
| RefSeq (Prot) | NP_418156 | ||||||
| UniProt | P0A988 | ||||||
| Other data | |||||||
| EC number | 2.7.7.7 | ||||||
| Chromosome | MG1655: 3.88 - 3.88 Mb | ||||||
| |||||||
See also
editReferences
edit- ^ PDB: 1MMI; Oakley AJ, Prosselkov P, Wijffels G, Beck JL, Wilce MC, Dixon NE (July 2003). "Flexibility revealed by the 1.85 Å crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III" (PDF). Acta Crystallogr. D. 59 (Pt 7): 1192–9. doi:10.1107/S0907444903009958. PMID 12832762.
- ^ Ohmori H, Kimura M, Nagata T, Sakakibara Y (May 1984). "Structural analysis of the dnaA and dnaN genes of Escherichia coli". Gene. 28 (2): 159–70. doi:10.1016/0378-1119(84)90253-1. PMID 6234204.
- ^ Armengod ME, García-Sogo M, Lambíes E (August 1988). "Transcriptional organization of the dnaN and recF genes of Escherichia coli K-12". J. Biol. Chem. 263 (24): 12109–14. PMID 2841344.
- ^ Stukenberg PT, Studwell-Vaughan PS, O'Donnell M (June 1991). "Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme". J. Biol. Chem. 266 (17): 11328–34. PMID 2040637.
 | This molecular biology article is a stub. You can help Wikipedia by expanding it. |