In enzymology, a diethyl 2-methyl-3-oxosuccinate reductase (EC 1.1.1.229) is an enzyme that catalyzes the chemical reaction
| diethyl 2-methyl-3-oxosuccinate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.229 | ||||||||
| CAS no. | 110369-21-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ diethyl 2-methyl-3-oxosuccinate + NADPH + H+
Thus, the two substrates of this enzyme are diethyl (2R,3R)-2-methyl-3-hydroxysuccinate and NADP+, whereas its 3 products are diethyl 2-methyl-3-oxosuccinate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase.
References
edit- Furuichi A, Akita H, Matsukura H, Oishi T, Horikoshi K (1987). "Purification and properties of an asymmetric reduction of diethyl 2-methyl-3-oxosuccinate in Saccharomyces fermentati". Agric. Biol. Chem. 51 (2): 293–299. doi:10.1271/bbb1961.51.293.
