Desosaminyl transferase EryCIII

Desosaminyl transferase EryCIII (EC 2.4.1.278, EryCIII) is an enzyme with systematic name dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

Desosaminyl transferase EryCIII
Identifiers
EC no.2.4.1.278
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins
dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B dTDP + erythromycin D

The enzyme is involved in erythromycin biosynthesis.

References

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  1. ^ Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S (October 2005). "In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides". Journal of the American Chemical Society. 127 (41): 14128–9. doi:10.1021/ja053704n. PMC 2525786. PMID 16218575.
  2. ^ Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S (August 2004). "Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway". Journal of the American Chemical Society. 126 (32): 9924–5. doi:10.1021/ja048836f. PMID 15303858.
  3. ^ Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF (January 2012). "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII". Journal of Molecular Biology. 415 (1): 92–101. doi:10.1016/j.jmb.2011.10.036. PMC 3391682. PMID 22056329.
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