Deoxypyridinoline, also called D-Pyrilinks, Pyrilinks-D, or deoxyPYD, is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones.[1] It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity. It is measured in urine tests and is used along with other bone markers such as alkaline phosphatase, osteocalcin, and N-terminal telopeptide to diagnose bone diseases such as postmenopausal osteoporosis, bone metastasis, and Paget's disease, furthermore, it has been useful in monitoring treatments that contain bone-active agents such as estrogens and bisphosphonates. [1]
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| Systematic IUPAC name
(2R)-6-{3-[(3S)-3-Amino-3-carboxypropyl]-4-[(2S)-2-amino-3-carboxyethyl]-5-hydroxypyridin-1-ium-1-yl}hexanoate | |
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PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C18H28N4O7 | |
| Molar mass | 412.43752 g mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Certain studies have attempted to generate a standardization of Deoxypyridinoline via an individual molar absorptivity value at acid and neutrality pH. The result was 5160 and 5290 L mol−1 cm−1 respectively.[2]
References
edit- ^ a b Rubinacci, A; Melzi, R; Zampino, M; Soldarini, A; Villa, I (1999). "Total and free deoxypyridinoline after acute osteoclast activity inhibition". Clinical Chemistry. 45 (9): 1510–6. doi:10.1093/clinchem/45.9.1510. PMID 10471654.
- ^ Robins, SP; Duncan, A; Wilson, N; Evans, BJ (1996). "Standardization of pyridinium crosslinks, pyridinoline and deoxypyridinoline, for use as biochemical markers of collagen degradation". Clinical Chemistry. 42 (10): 1621–6. doi:10.1093/clinchem/42.10.1621. PMID 8855145.