Darbinyan or Darbinian, (Armenian: Դարբինյան), is an Armenian surname. Its meaning is equivalent to Smith (Armenian: Դարբին). Darbinyan is the Eastern Armenian form of the name, the Western Armenian variant being Tarpinian. Notable people with the surname include:
- Armen Darbinyan (born 1965), Armenian politician and Prime Minister of Armenia
- Eduard Darbinyan
- Margarita Darbinyan
- Samvel Darbinyan, Armenian football manager
- Jeff Tarpinian, American football player with the New England Patriots
- Robert Darbinyan
- Ruben Darbinyan (1883-1968), Armenian politician, Justice minister, political activist, author and editor