DLX1

Not to be confused with DLX-001.

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.

DLX1
Identifiers
Aliases	DLX1, Dlx, Dlx-1, distal-less homeobox 1
External IDs	OMIM: 600029; MGI: 94901; HomoloGene: 22558; GeneCards: DLX1; OMA:DLX1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q31.1 Start 172,084,740 bp End 172,089,677 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 C2|2 42.61 cM Start 71,358,457 bp End 71,364,325 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus testicle anterior cingulate cortex endothelial cell ganglionic eminence prefrontal cortex Brodmann area 23 dorsolateral prefrontal cortex primary visual cortex Brodmann area 9 Top expressed in medial ganglionic eminence olfactory bulb nasolacrimal duct Rostral migratory stream otic vesicle otic placode lateral septal nucleus fossa paraventricular nucleus of hypothalamus maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity Cellular component nucleus Biological process negative regulation of neuron apoptotic process cerebral cortex GABAergic interneuron differentiation proximal/distal pattern formation cell differentiation regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II embryonic skeletal system development multicellular organism development odontogenesis of dentin-containing tooth cerebral cortex GABAergic interneuron fate commitment negative regulation of oligodendrocyte differentiation forebrain neuron differentiation hippocampus development subpallium development negative regulation of Notch signaling pathway positive regulation of cell differentiation negative regulation of photoreceptor cell differentiation positive regulation of amacrine cell differentiation negative regulation of transcription by RNA polymerase II negative regulation of BMP signaling pathway positive regulation of transcription by RNA polymerase II cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus negative regulation of cellular response to transforming growth factor beta stimulus transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1745 13390 Ensembl ENSG00000144355 ENSMUSG00000041911 UniProt P56177 Q64317 RefSeq (mRNA) NM_001038493 NM_178120 NM_010053 RefSeq (protein) NP_001033582 NP_835221 NP_034183 Location (UCSC) Chr 2: 172.08 – 172.09 Mb Chr 2: 71.36 – 71.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Letinic K, Zoncu R, Rakic P (2002). "Origin of GABAergic neurons in the human neocortex". Nature. 417 (6889): 645–9. Bibcode:2002Natur.417..645L. doi:10.1038/nature00779. PMID 12050665. S2CID 4349070.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chiba S, Takeshita K, Imai Y, et al. (2004). "Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15577–82. doi:10.1073/pnas.2536757100. PMC 307610. PMID 14671321.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhou QP, Le TN, Qiu X, et al. (2004). "Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation". Nucleic Acids Res. 32 (3): 884–92. doi:10.1093/nar/gkh233. PMC 373381. PMID 14769946.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Hamilton SP, Woo JM, Carlson EJ, et al. (2006). "Analysis of four DLX homeobox genes in autistic probands". BMC Genet. 6: 52. doi:10.1186/1471-2156-6-52. PMC 1310613. PMID 16266434.