DLGAP4

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.

DLGAP4
Identifiers
Aliases	DLGAP4, DAP-4, DAP4, DLP4, SAPAP-4, SAPAP4, discs large homolog associated protein 4, DLG associated protein 4
External IDs	OMIM: 616191; MGI: 2138865; HomoloGene: 8935; GeneCards: DLGAP4; OMA:DLGAP4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.23 Start 36,306,336 bp End 36,528,637 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 156,455,625 bp End 156,606,283 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ascending aorta skin of leg right coronary artery Descending thoracic aorta popliteal artery tibial arteries skin of abdomen gastrocnemius muscle left coronary artery Top expressed in superior frontal gyrus genital tubercle lip granulocyte zygote primary visual cortex Rostral migratory stream subiculum internal carotid artery ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein domain specific binding Cellular component membrane plasma membrane synapse neuromuscular junction glutamatergic synapse cholinergic synapse postsynaptic specialization Biological process signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22839 228836 Ensembl ENSG00000080845 ENSMUSG00000061689 UniProt Q9Y2H0 B1AZP2 RefSeq (mRNA) NM_001042486 NM_014902 NM_183006 NM_001365621 NM_001042487 NM_001042488 NM_001277186 NM_001277187 NM_146128 RefSeq (protein) NP_001035951 NP_055717 NP_892118 NP_001352550 NP_001035952 NP_001035953 NP_001264115 NP_001264116 NP_666240 Location (UCSC) Chr 20: 36.31 – 36.53 Mb Chr 2: 156.46 – 156.61 Mb PubMed search
Wikidata
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Function

DAP-4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. DAP-4 can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Further reading

• Kim JH, Liao D, Lau LF, Huganir RL (1998). "SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family". Neuron. 20 (4): 683–91. doi:10.1016/S0896-6273(00)81008-9. PMID 9581761. S2CID 12247592.
• Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II". Neuron. 20 (5): 895–904. doi:10.1016/S0896-6273(00)80471-7. PMID 9620694. S2CID 14655729.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Kawabe H, Hata Y, Takeuchi M, et al. (1999). "nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP)". J. Biol. Chem. 274 (43): 30914–8. doi:10.1074/jbc.274.43.30914. PMID 10521485.
• Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. hdl:1842/742. PMID 10862698. S2CID 14392630.
• Pei L, Teves RL, Wallace MC, Gurd JW (2001). "Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP". J. Cereb. Blood Flow Metab. 21 (8): 955–63. doi:10.1097/00004647-200108000-00008. PMID 11487731.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Riefler GM, Balasingam G, Lucas KG, et al. (2003). "Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)". Biochem. J. 373 (Pt 1): 49–55. doi:10.1042/BJ20021838. PMC 1223477. PMID 12675619.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Song B, Yan XB, Zhang GY (2004). "PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus". Brain Res. 1005 (1–2): 44–50. doi:10.1016/j.brainres.2004.01.032. PMID 15044063. S2CID 33854259.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.