DAPP1

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.

DAPP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FAO, 1FB8
Identifiers
Aliases	DAPP1, BAM32, dual adaptor of phosphotyrosine and 3-phosphoinositides, dual adaptor of phosphotyrosine and 3-phosphoinositides 1
External IDs	OMIM: 605768; MGI: 1347063; HomoloGene: 32138; GeneCards: DAPP1; OMA:DAPP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q23 Start 99,816,827 bp End 99,870,190 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G3 Start 137,636,768 bp End 137,687,306 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid epithelium of nasopharynx monocyte buccal mucosa cell mucosa of paranasal sinus oral cavity epithelium of bronchus bronchial epithelial cell palpebral conjunctiva sperm Top expressed in epithelium of small intestine granulocyte spermatocyte seminiferous tubule spermatid blood zygote conjunctival fornix tibiofemoral joint bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phospholipid binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding PDZ domain binding Cellular component cytosol plasma membrane membrane cytoplasm Biological process protein dephosphorylation signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27071 26377 Ensembl ENSG00000070190 ENSMUSG00000028159 UniProt Q9UN19 Q9QXT1 RefSeq (mRNA) NM_001306151 NM_014395 NM_011932 NM_001310753 RefSeq (protein) NP_001293080 NP_055210 NP_001297682 NP_036062 Location (UCSC) Chr 4: 99.82 – 99.87 Mb Chr 3: 137.64 – 137.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Marshall AJ, Niiro H, Lerner CG, et al. (2000). "A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase". J. Exp. Med. 191 (8): 1319–32. doi:10.1084/jem.191.8.1319. PMC 2193139. PMID 10770799.
• Dowler S, Montalvo L, Cantrell D, et al. (2001). "Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase". Biochem. J. 349 (Pt 2): 605–10. doi:10.1042/0264-6021:3490605. PMC 1221184. PMID 10880360.
• Ferguson KM, Kavran JM, Sankaran VG, et al. (2000). "Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains". Mol. Cell. 6 (2): 373–84. doi:10.1016/S1097-2765(00)00037-X. PMID 10983984.
• Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Stephens LR, Anderson KE, Hawkins PT (2001). "Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines". J. Biol. Chem. 276 (46): 42767–73. doi:10.1074/jbc.M107194200. PMID 11524430.
• Niiro H, Maeda A, Kurosaki T, Clark EA (2002). "The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival". J. Exp. Med. 195 (1): 143–9. doi:10.1084/jem.20011524. PMC 2196019. PMID 11781373.
• Marshall AJ, Krahn AK, Ma K, et al. (2002). "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor". Mol. Cell. Biol. 22 (15): 5479–91. doi:10.1128/MCB.22.15.5479-5491.2002. PMC 133950. PMID 12101241.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Han A, Saijo K, Mecklenbräuker I, et al. (2003). "Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival". Immunity. 19 (4): 621–32. doi:10.1016/S1074-7613(03)00275-9. PMID 14563325.
• Allam A, Niiro H, Clark EA, Marshall AJ (2004). "The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism". J. Biol. Chem. 279 (38): 39775–82. doi:10.1074/jbc.M403367200. PMID 15247305.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Niiro H, Allam A, Stoddart A, et al. (2004). "The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization". J. Immunol. 173 (9): 5601–9. doi:10.4049/jimmunol.173.9.5601. PMID 15494510.