d-DOPA (D-3,4-dihydroxyphenylalanine; dextrodopa) is similar to L-DOPA (levodopa), but with opposite chirality. Levo- and dextro- rotation refer to a molecule's ability to rotate planes of polarized light in one or the other direction. Whereas L-DOPA is moderately effective in the treatment of Parkinson's disease (PD) and dopamine-responsive dystonia (DRD) by stimulating the production of dopamine in the brain, D-DOPA is biologically inactive.
Names | |
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IUPAC name
3,4-Dihydroxy-D-phenylalanine
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Systematic IUPAC name
(2R)-2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid | |
Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.024.858 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C9H11NO4 | |
Molar mass | 197.19 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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See also
edit- l-DOPA (Levodopa; Sinemet, Parcopa, Atamet, Stalevo, Madopar, Prolopa, etc.)
- l-DOPS (Droxidopa)
- Methyldopa (Aldomet, Apo-Methyldopa, Dopamet, Novomedopa, etc.)
- Dopamine (Intropan, Inovan, Revivan, Rivimine, Dopastat, Dynatra, etc.)
- Norepinephrine (Noradrenaline; Levophed, etc.)
- Epinephrine (Adrenaline; Adrenalin, EpiPen, Twinject, etc.)
References
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