In enzymology, a crotonoyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58) is an enzyme that catalyzes the chemical reaction
| crotonoyl-[acyl-carrier-protein] hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.58 | ||||||||
| CAS no. | 9030-78-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] but-2-enoyl-[acyl-carrier-protein] + H2O
Hence, this enzyme has one substrate, [[(3R)-3-hydroxybutanoyl-[acyl-carrier-protein]]], and two products, [[but-2-enoyl-[acyl-carrier-protein]]] and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase (but-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase, beta-hydroxybutyryl acyl carrier protein dehydrase, beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase, beta-hydroxybutyryl acyl carrier protein dehydrase, enoyl acyl carrier protein hydrase, crotonyl acyl carrier protein hydratase, 3-hydroxybutyryl acyl carrier protein dehydratase, beta-hydroxybutyryl acyl carrier, and protein dehydrase. This enzyme participates in fatty acid biosynthesis.
References
edit- MAJERUS PW, ALBERTS AW, VAGELOS PR (1965). "ACYL CARRIER PROTEIN. 3. AN ENOYL HYDRASE SPECIFIC FOR ACYL CARRIER PROTEIN THIOESTERS". J. Biol. Chem. 240: 618–21. PMID 14275113.
- Mizugaki M, Weeks G, Toomey RE, Wakil SJ (1968). "Studies on the mechanism of fatty acid synthesis. XX. Preparation and general properties of beta-hydroxybutyryl acyl carrier protein dehydrase". J. Biol. Chem. 243 (13): 3661–70. PMID 5658542.
