Colon cancer associated transcript 1

Colon cancer associated transcript 1 is a long non-coding RNA that, in humans, is encoded by the CCAT1 gene.

CCAT1
Identifiers
Aliases	CCAT1, CARLo-5, onco-lncRNA-40, colon cancer associated transcript 1 (non-protein coding), CARLO5, colon cancer associated transcript 1
External IDs	OMIM: 617705; GeneCards: CCAT1; OMA:CCAT1 - orthologs
Orthologs Species Human Mouse Entrez 100507056 n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a
Wikidata
View/Edit Human

This gene produces a long non-coding RNA that promotes tumor formation and is upregulated in colon cancer and other cancer cell types. This transcript may regulate long range chromosomal interactions, including at the Myc oncoprotein locus. This RNA may also function as a molecular sponge for microRNAs.

Further reading

• Nissan A, Stojadinovic A, Mitrani-Rosenbaum S, Halle D, Grinbaum R, Roistacher M, Bochem A, Dayanc BE, Ritter G, Gomceli I, Bostanci EB, Akoglu M, Chen YT, Old LJ, Gure AO (2012). "Colon cancer associated transcript-1: a novel RNA expressed in malignant and pre-malignant human tissues". Int. J. Cancer. 130 (7): 1598–606. doi:10.1002/ijc.26170. hdl:11693/21512. PMID 21547902.
• Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y, Fang G (2013). "Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma". J. Cancer Res. Clin. Oncol. 139 (3): 437–45. doi:10.1007/s00432-012-1324-x. PMID 23143645. S2CID 667876.
• Alaiyan B, Ilyayev N, Stojadinovic A, Izadjoo M, Roistacher M, Pavlov V, Tzivin V, Halle D, Pan H, Trink B, Gure AO, Nissan A (2013). "Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence". BMC Cancer. 13: 196. doi:10.1186/1471-2407-13-196. PMC 3639026. PMID 23594791.
• Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO, Wu Z, Zhang S, Wang HB, Ge J, Lu X, Yang L, Chen LL (2014). "Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus". Cell Res. 24 (5): 513–31. doi:10.1038/cr.2014.35. PMC 4011346. PMID 24662484.
• Luo J, Tang L, Zhang J, Ni J, Zhang HP, Zhang L, Xu JF, Zheng D (2014). "Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer". Tumour Biol. 35 (11): 11541–9. doi:10.1007/s13277-014-2442-7. PMID 25129441. S2CID 17249302.
• Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, Gong W, Quan ZW (2015). "Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p". Cell Death Dis. 6 (1): e1583. doi:10.1038/cddis.2014.541. PMC 4669740. PMID 25569100.
• Zhang Y, Ma M, Liu W, Ding W, Yu H (2014). "Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer". Int J Clin Exp Pathol. 7 (12): 8471–9. PMC 4314006. PMID 25674211.
• Cabanski CR, White NM, Dang HX, Silva-Fisher JM, Rauck CE, Cicka D, Maher CA (2015). "Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function". RNA Biol. 12 (6): 628–42. doi:10.1080/15476286.2015.1038012. PMC 4615893. PMID 25864709.
• Deng L, Yang SB, Xu FF, Zhang JH (2015). "Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge". J. Exp. Clin. Cancer Res. 34 (1): 18. doi:10.1186/s13046-015-0136-7. PMC 4339002. PMID 25884472.
• Zhu H, Zhou X, Chang H, Li H, Liu F, Ma C, Lu J (2015). "CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion". Int J Clin Exp Pathol. 8 (5): 5427–34. PMC 4503117. PMID 26191246.