Colo-Colo is a Chilean men's football club based in Macul, Santiago.
Colo-Colo may also refer to:
- Colo-colo (condiment), a spicy Indonesian condiment
- Colo Colo (mythology), a rat-like creature from Mapuche mythology
- Colo-Colo (women), a Chilean women's football club
- Colo-Colo B, a Chilean men's football team
- Chilean ship Colo Colo, a list of ships