Co-danthrusate is a combination of dantron and docusate. Dantron is a mild peristaltic stimulant which acts on the lower bowel to encourage normal bowel movement without causing irritation. It belongs to the group of medicines under the term stimulant laxative.[1] It stimulates the nerves in the stomach wall, which causes the stomach muscles to contract. This medicine is used for analgesic-induced constipation. It takes six to twelve hours to work.[2] This can cause discoloration of urine and bowel and liver tumors.[3]
| Combination of | |
|---|---|
| Dantron | stimulant laxative |
| Docusate | laxative |
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| CAS Number | |
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Co-danthramer is dantron plus poloxamer. It is (in the U.K.) only to be prescribed to terminally ill patients because of its carcinogenicity in rats. It is often prescribed to people taking long term opioid, because it relaxes the effect of opioid induced constipation. It will not alleviate the symptoms of opioid induced delayed gastric emptying and abdominal cramps.[4]
See also
editReferences
edit- ^ "Constipation in Adults information. Causes and Treatment". patient.info.
- ^ "Co-danthrusate". 20 August 2007. Archived from the original on 2007-08-20.
- ^ "co-danthrusate suspension". Medthority.com. Archived from the original on 2021-04-12.
- ^ Ahmedzai SH, Boland J (April 2010). "Constipation in people prescribed opioids". BMJ Clinical Evidence. 2010. PMC 2907601. PMID 21718572.