Clofibride

Clofibride
Clinical data
ATC code	C10AB10 (WHO) ;
Pharmacokinetic data
Metabolism	Hydrolyzed to clofibric acid; hepatic glucuronidation
Elimination half-life	12 hours (clofibric acid)
Excretion	Renal (mostly) and fecal
Identifiers
	IUPAC name 3-(dimethylcarbamoyl)propyl 2-(4-chlorophenoxy)-2-methylpropanoate;
CAS Number	26717-47-5;
PubChem CID	160134;
ChemSpider	140758 ;
UNII	0S9SLS3L93;
KEGG	D07188 ;
ChEMBL	ChEMBL1697831;
CompTox Dashboard (EPA)	DTXSID1022841 ;
ECHA InfoCard	100.043.542
Chemical and physical data
Formula	C16H22ClNO4
Molar mass	327.81 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(OC(C(=O)OCCCC(=O)N(C)C)(C)C)cc1;
	InChI InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3 ; Key:CXQGFLBVUNUQIA-UHFFFAOYSA-N ;
	(verify)

Clofibride is a fibrate. Clofibride is a derivative of clofibrate. In the body it is converted into 4-chlorophenoxyisobutyric acid (clofibric acid),^[1] which is the true hypolipidemic agent.^[2] So clofibride, just like clofibrate is a prodrug of clofibric acid.

References

^ "Clofibride".
^ Entry on Clofibrat. at: Römpp Online. Georg Thieme Verlag, retrieved 06. Mai 2020.

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[1] "Clofibride".

[römpp-2] Entry on Clofibrat. at: Römpp Online. Georg Thieme Verlag, retrieved 06. Mai 2020.

[1]

[2]

Clinical data

ATC code	C10AB10 (WHO)
Pharmacokinetic data
Metabolism	Hydrolyzed to clofibric acid; hepatic glucuronidation
Elimination half-life	12 hours (clofibric acid)
Excretion	Renal (mostly) and fecal
Identifiers
IUPAC name 3-(dimethylcarbamoyl)propyl 2-(4-chlorophenoxy)-2-methylpropanoate
CAS Number	26717-47-5
PubChem CID	160134
ChemSpider	140758^Y
UNII	0S9SLS3L93
KEGG	D07188^Y
ChEMBL	ChEMBL1697831
CompTox Dashboard (EPA)	DTXSID1022841
ECHA InfoCard	100.043.542
Chemical and physical data
Formula	C₁₆H₂₂ClNO₄
Molar mass	327.81 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1ccc(OC(C(=O)OCCCC(=O)N(C)C)(C)C)cc1
InChI InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3^Y Key:CXQGFLBVUNUQIA-UHFFFAOYSA-N^Y
(verify)