Class II PI 3-kinases

Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.

Class II PI 3-kinases were the most recently identified class of PI 3-kinases.

There are three class II PI 3-kinase isoforms expressed in mammalian cells;

• PI3K-C2α encoded by the PIK3C2A gene
• PI3K-C2β encoded by the PIK3C2B gene
• PI3K-C2γ encoded by the PIK3C2G gene

See also

• Phosphoinositide 3-kinase

References

• Stein RC (September 2001). "Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment". Endocrine-Related Cancer. 8 (3): 237–248. doi:10.1677/erc.0.0080237. PMID 11566615.
• Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". Journal of Cell Science. 116 (Pt 15): 3037–3040. doi:10.1242/jcs.00609. PMID 12829733.
• Vanhaesebroeck B, Waterfield MD (November 1999). "Signaling by distinct classes of phosphoinositide 3-kinases". Experimental Cell Research. 253 (1): 239–254. doi:10.1006/excr.1999.4701. PMID 10579926.