Wikipedia

Chocolate addiction

Chocolate addiction is a compulsive desire to eat chocolate despite negative consequences.

Dark chocolate

There is medical evidence to support the existence of addiction to chocolate.[1] Psychoactive constituents of chocolate that trigger a ‘feel-good’ reaction for the consumer include tryptophan and phenylethylamine, which may contribute to cravings and addiction-like responses, particularly in people with specific genetic alleles.[2] The quantity of sugars used in chocolate confections also impacts the psychoactive effects of chocolate.[3]

Although the concept of a chocolate addiction is still controversial in the medical literature, chocolate (especially dark chocolate) is considered to have effects on mood,[4] and chocolate confectioneries almost always top the list of foods people say they crave.[5] The craving can be so strong in some cases that chocoholics may experience withdrawal symptoms if the craving is not fulfilled.[6]

The word chocoholic is used humorously to describe a person who is inordinately fond of chocolate.[citation needed] The term was first used in 1961, according to Merriam-Webster. It is a portmanteau of "chocolate" and "alcoholic".[7]

Addiction

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There are two factors that contribute to the addictive nature of chocolate. The first is the pharmacological ingredients, and the second is the additives.[2] The essential components of addiction are intense craving for something and a loss of control over its use. Academic research has shown that people can exhibit both of these components in relation to food, particularly food that contains sugar or fat. Since chocolate contains both, it is often used in studies of food addiction.[8]

Criticism

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A study in the journal Nutrients has shown that despite some evidence that this type of addiction exists, there is no formal diagnosis given in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).[9] It is known that chocolate consumption does not activate the shell of the nucleus accumbens, as seen in those with substance use disorders.[2]

Genetics

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A study published in the journal Cell Metabolism proved a correlation between the FGF21 gene and a liking for sweet foods.[10] Other research has upheld one of the variants of the FGF21 gene were 20% more likely to crave sugary foods.[10][11] The FGF21 gene also moderates appetite and controls insulin resistance.[10] The FGF21 gene is also known to be associated with the sweet tooth.[12][13]

It is also known that there is an association between the FTO gene and intake of sugar and caffeine.[14] The FTO gene works to regulate the body's energy usage.[14] Some variants of the FTO gene play a major role in the connectivity in the reward circuit of the meso-striato prefrontal regions, which act to process information and focus one's attention, and are linked to disorders such as addiction.[15] Studies have found that the presence of chromosome 16 can uphold genetic variations that influence the intake of sweet foods, such as chocolate.[15][16]

The dopamine receptor D2 is also linked to addictive behaviours such as substance use disorders. Addiction may occur when there is a deficit in the number of dopamine 2 receptors, which gives one the ability to experience pleasure.[17]

A study in the Journal of Psychoactive Drugs has shown that the biological children of alcoholic parents are at a higher risk to inherit a preference for sweet foods, including chocolate.[17]

People develop the preference for sweet-tasting foods from birth, as it is related to the taste of mother's milk and the way it provides a sense of calmness to newborns.[18] People also quickly learn to prefer energy-rich foods, such as chocolate, which the appetite learns to want, even when not hungry.[19]

Craving

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The World's Biggest Chocolate Consumers; Forbes, 2019

Even scientists who doubt the existence of true addiction agree that chocolate craving is real.[6] Chocolate is one of the most commonly craved foods due to a variety of reasons.[19] The pleasant taste creates a pleasurable experience for the consumer.[2] The combination of the sweetness, smoothness and creaminess in terms of both taste and smell creates an ideal sensory attraction.[20] Chocolate's high energy density also contributes to the consumer experience.[21] This desire is created through a motivational circuitry in the brain that influences behaviours without conscious awareness, which generates a craving for chocolate.[19] The consumption of chocolate creates a positive emotional experience, providing comfort and often used for alleviating stress and negative emotions. Chocolate is known to regulate an imbalance in the functioning of the neurotransmitter, serotonin, a factor influencing emotional states. Chocolate's fat and energy contents makes the food a key preference when under stress.[19]

Chocolate cravings are also as a result of nutrient deficits. Cravings can be a result of needing to increase magnesium levels to correct an imbalance in neurotransmitters that work to regulate disposition and digestion.[18][22] An imbalance of blood sugar levels also increases cravings. The releasing of insulin to lower blood sugar when sugar is ingested results in a long-term imbalance which results in cravings for sugar in order to raise energy.[23]

Women are especially affected.[24][25] Fluctuating hormone levels among women is also known to contribute towards chocolate cravings. Studies have shown that those during menstruation or suffering from premenstrual syndrome (PMS) recorded more severe cravings for foods with high sugar and fat contents, such as chocolate, compared to women at different stages of the menstruation cycle.[6] Magnesium deficits are also known to enhance the symptoms of premenstrual syndrome (PMS), which contributes to a higher chocolate craving.[6]

Cravings for chocolate can also be triggered or stimulated by the senses.[26] The odour of chocolate is known to increase brain activity and cravings when compared with tests with no odour involved.[26] For those who crave chocolate regularly, the sight of chocolate activates the orbitofrontal cortex and ventral striatum, both associated with reward-related behaviour and decision making.[26][27]

Management techniques

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Blood sugar

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Implementation of nutritional changes can assist in overcoming a chocolate addiction. Consumption of foods such as proteins and healthy fats prevent large amounts of insulin to be released. The release of excessive amounts of insulin results in chocolate cravings. The amino acid within protein assists in building chemicals such as dopamine, which can help to reduce chocolate cravings. Foods containing fibre can also assist to balance blood sugar and slow digestion. Increasing consumption of foods rich in iron, works to decrease the body's need for an energy boost through sugar.[28] This can include foods such as beans, lentils and leafy dark green vegetables. Eating regular meals also stabilises blood sugar levels.[23] Adhering to a nutritious meal plan with planned meals and snacks assists in reducing the likelihood of chocolate cravings.[23][29]

Chocolate cravings can also be linked to stress. Stress raises blood sugar levels through the hormone cortisol and the releasing of glucose from the liver. A lack of sleep also results in increased sugar consumption as people seek to overcome fatigue. Increasing the number of hours of sleep can assist to reduce the need to consume chocolate.[30]

Studies have shown that consuming artificial sweeteners such as aspartame, saccharin, and sucralose increase chocolate cravings.[31] This is due to the fact that they are equally sweet and encourage a sugar dependence.[23][32]

Reversing an insulin resistance can also work to curb cravings for chocolate. This can be achieved through the consumption of substances such as cinnamon (which also may be used as a natural sugar substitute), ginger, and turmeric, that stimulates the absorption of glucose in the body.[23][33][34]

Caffeine

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Biscuits using carob powder instead of cocoa powder

Introducing substitute products into diets can assist in reducing the craving for chocolate. This could include products such as carob. Carob does not contain theobromine or caffeine, both addictive methylxanthine substances.[18] However, 100 grams carob contains 49.1 grams sugars.[35]

Cause by ingredients

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Cocoa bean

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Main article: Cocoa bean
 
Cacao nibs, pieces of cocoa kernels, generally powdered and melted into chocolate liquor, but also inserted into chocolate bars to give additional "crunch"

Chocolate liquor is produced from cocoa beans that have been fermented, dried, roasted, and separated from their skins. The beans are ground into cocoa mass (cocoa paste). The mass is melted to become the liquor, and the liquor is either separated into cocoa solids and cocoa butter, or cooled and molded into blocks of raw chocolate. Its main use (often with additional cocoa butter) is in making chocolate.

Cocoa solids

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Main article: Cocoa solids

Cocoa powder contains several substances that can make it feel "addictive". However, theobromine is the primary compound found in cocoa. Also, dark chocolate contains higher amounts of these substances due to its higher cocoa content.

  • Anandamide: Binds to receptors in the brain called the cannabinoid receptor. The presence of anandamide imitates the psychoactive effects similar to cannabis.[36][2] Anandamide is also known to regulate mood and reduce anxiety.[37] Also, dark chocolate also contains higher amounts of anandamide due to its higher cocoa content.[38]
  • Methylxanthines: Caffeine and theobromine which act as an energizer and impact performance.[36]
    • Caffeine: 10 grams unsweetened cocoa solids contains 23 mg caffeine.[39] Consumption of 100 mg caffeine (or 43 grams cocoa solids) per day may cause low-dose symptoms of caffeinism.
    • Theobromine: Per 50 g, dark chocolate also contains up to 220 mg of theobromine, compared to 75 mg in milk chocolate.[26] Anecdotal evidence suggests that long-term use of 600 mg theobromine may induce withdrawal symptoms such as headache, muscle tension, and lethargy that can be reversed with 200 mg.[40]
  • Precursors to neurotransmitters, and neurotransmitters:
    • Dopamine precursors
    • Phenethylamine, a neurotransmitter from which amphetamine is derived.[41] The characteristics of phenylethylamine have led to it being nicknamed "chocolate amphetamine”.[41][2] Phenylethylamine triggers the "reward centres" in the brain, which entices repeat behaviour by the consumer. Phenylethylamine is also known to be released by the brain when we fall in love.[37] In instances where chocolate consists of sufficient phenylethylamine, an addiction is likely to occur.[2]
    • Tryptophan: 10 grams unsweetened cocoa solids contains 29 mg tryptophan.[39] An essential amino acid that is a precursor to serotonin, a neurotransmitter involved in regulating moods. This encourages the user to consume more chocolate due to its ability to make the consumer feel good.[42]
  • Salsolinol is a psychoactive compound found within chocolate which links to the dopamine receptor D2 and dopamine receptor D3 to the reward centres in the brain. Salsolinol is known to contribute towards a craving for chocolate. Studies have shown that the concentration of salsolinol in chocolate depends on its cocoa content. Milk chocolate types contains 30% cocoa, whilst dark chocolate types uphold 60-70% cocoa.[43]

Heightened brain chemicals:

  • Enkephalin: The natural brain chemical enkephalin is heightened when chocolate is consumed. Enkephalin triggers opioid receptors similar to those triggered by heroin and morphine use. This chemical leads the brain to desire more after chocolate is initially consumed, which can lead to addiction.[44]

Cravings -- Dark chocolate may cause cravings if a person's micronutrient levels are low:

  • Magnesium: Dark chocolate contains 252.2 mg/100 g,[45] while milk chocolate containing 63 mg/100g. It is estimated that the magnesium levels in white chocolate is 12 times less compared to milk chocolate.[36]

Cocoa butter

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About 54–58% of the cocoa nibs is cocoa butter.

Raw chocolate

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Main article: Raw chocolate

Raw chocolate contains cocoa solids and cocoa butter, from the cacao beans.

Dark chocolates' high caffeine and theobromine content can cause addiction due to both of their psychological effects.[18] This is as a result of its higher content of cacao compared to other forms of chocolate. The amount of caffeine in dark chocolate can vary from 35 to 200 mg 50 g−1 while milk chocolate contains lower amounts of caffeine (14 mg 50 g−1).[26]

Additives

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See also: Types of chocolate

The additives of sugar and fat in both milk chocolate and white chocolate trigger sweet taste receptors which releases dopamine and entice consumption to be repeated. This experience is seen to be more enjoyable compared to dark chocolate which upholds bitter aftertastes.[46]

Alcohol

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Main article: Chocolate liqueur
 
A bottle of chocolate liqueur

Chocolate liqueur is a liqueur made from a base liquor of whisky or vodka with chocolate as an additive. Unlike chocolate liquor, chocolate liqueur does contain alcohol and is often used as a sweetening ingredient in mixology, baking, and cooking.

Chronic alcohol abuse that results in significant health problems is the cause of alcoholism.

Sugars

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See also: § Blood sugar management
 
A glass of chocolate milk.
 
White chocolate

Most products (except dark chocolate) includes both significant amount of sugars and the psychoactive substances' cocoa solids. In combining these two components, milk chocolate is the most preferred by consumers.[36] Commercial products which most typically contains sugar may lead to addiction and continued use despite negative consequences.

Products with sugars, including milk sugar:

White chocolate does not contain cacao or cocoa solids, instead made up of cocoa butter, milk solids, sugar and fat. It is known that the fat and sugar content in white chocolate is what makes this chocolate addictive.[2] In manufacturing white chocolate, the rough textures of the cocoa solids are removed, leaving the smoothness of the cocoa butter. This creates a pleasurable experience for the consumer as there is not grit left on the tongue.[47] Refining the sugar in the mixture to remove any rough textures also creates a positive sensory experience for the consumer. These smoothing processes are referred to as conching.[48] The ‘melt in your mouth’ aspect due to its high cocoa content also contributes to a craving for white chocolate.[49]

History

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See also: History of chocolate
 
An advertisement promoting the benefits of consuming cocoa from 1910 in Canadian Journal of Public Health

It is estimated that chocolate has been consumed for over 2000 years. Most of its history, it has been consumed as a liquid, with it only being developed into a powdered form in the mid 1800s.[50] Throughout Europe during this time, chocolate was regarded as an exciting beverage, developing great popularity and desire by its consumers.[51] In ancient Mexico, chocolate was served only to adult males such as government officials, military officers, priests and distinguished warriors. Chocolate was also seen as intoxicating and stimulating and therefore not appropriate of use by children and women. Ancient emperors such as Moctezuma II was said to utilise chocolate as an aphrodisiac,[52] consuming large amounts before visiting his wives.[51] Casanova also consumed the chocolate in liquid form before seeing his romantic partners. Chocolate is often referred to as the “love drug”, which began the trend of exchanging chocolates on Valentine's Day as early as the 17th century.[53]

Chocolate and its psychological effects was kept a secret throughout its origin in Spain during the 16th century, until the early 17th century when Madrid became a hub for fashion and society.[54] Visitors travelling throughout Spain came to discover the taste of chocolate. Spanish monks also taught visiting family members the habit of consuming hot chocolate and its health benefits.[54][55] Early studies by Spanish monk Bernardino de Sahagún advised against overconsumption of cacao, reporting that large amounts of green cacao resulted in consumers feeling disorientated. He applauded smaller doses of chocolate, advising that chocolate consumed as a liquid resulted in consumers feeling revitalised.[55]

Chocolate also had a significant medical use. The drinking of chocolate was seen to improve digestion and heavy stomachs as it was previously known to promote healthy gut bacteria. It was also utilised for treatment for those with wasting diseases such as tuberculosis.[56] The strong taste of cacao was also used to hide the flavour of unpleasant tasting drugs which has developed into a modern view of “a little bit of chocolate makes the medicine go down".[51] Chocolates use also extended to treating those with bloody dysentery.[51]

Chocolate usage was also linked to its nutritional benefits. English soldiers based in Jamaica in the 17th century survived on cacao paste dissolved in water with sugar over long periods of time, without showing any decline in strength. It is also known that Indian women would consume it so frequently and in such large amounts that it would become a replacement for meat.[56]

See also

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References

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  1. ^ Hetherington, Marion M.; MacDiarmid, Jennifer I. (1993). "'Chocolate Addiction': A Preliminary Study of its Description and its Relationship to Problem Eating". Appetite. 21 (3): 233–46. doi:10.1006/appe.1993.1042. PMID 8141595. S2CID 36613545.
  2. ^ a b c d e f g h Nehlig, Astrid (2004). Coffee, tea, chocolate, and the brain. Boca Raton: CRC Press. pp. 203–218. ISBN 9780429211928.
  3. ^ Casperson, Shanon L; Lanza, Lisa; Albajri, Eram; Nasser, Jennifer A (2019-03-12). "Increasing Chocolate's Sugar Content Enhances Its Psychoactive Effects and Intake". Nutrients. 11 (3): 596. doi:10.3390/nu11030596. PMC 6471517. PMID 30870996.
  4. ^ Jackson, Sarah E; Smith, Lee; Firth, Joseph; et al. (2019). "Is there a relationship between chocolate consumption and symptoms of depression? A cross-sectional survey of 13,626 US adults". Depress Anxiety. 36 (10): 987–995. doi:10.1002/da.22950. hdl:10447/464591. PMID 31356717. S2CID 198984561.
  5. ^ Rogers, Peter (2003). "Food cravings and addictions – fact and fallacy". In Carr, Tanya; Descheemaeker, Koen (eds.). Nutrition and Health - Current topics - 3. Antwerpen: Garant. pp. 69–76. ISBN 978-90-441-1493-5.
  6. ^ a b c d Bruinsma, Kristen; Taren, Douglas L. (1999). "Chocolate: Food or Drug?". Journal of the American Dietetic Association. 99 (10): 1249–56. doi:10.1016/S0002-8223(99)00307-7. PMID 10524390.
  7. ^ "Chocoholic". Merriam-Webster. Retrieved 14 April 2013.
  8. ^ Miller, Michael Craig (February 14, 2013). "Can you become addicted to chocolate?". Harvard Health Blog. Harvard University. Retrieved 14 April 2013.
  9. ^ Meule, Adrian; Gearhardt, Ashley N. (2014-09-16). "Food Addiction in the Light of DSM-5". Nutrients. 6 (9): 3653–3671. doi:10.3390/nu6093653. PMC 4179181. PMID 25230209.
  10. ^ a b c Adams, Andrew; Gimeno, Ruth (2016). "The Sweetest Thing: Regulation of Macronutrient Preference by FGF21". Cell Metab. 23 (2): 227–228. doi:10.1016/j.cmet.2016.01.013. PMID 26863484.
  11. ^ Maron, Dina Fine (2017). "Crave Sugar? Maybe It's in Your Genes". Scientific American. Retrieved May 19, 2020.
  12. ^ Noone, Yasmin (2020). "Plan to binge on milk chocolate this Easter? Blame your brain and genes". SBS News. Retrieved May 19, 2020.
  13. ^ Grarup, Niels (2018). "Going hedonic - the role of FGF21 in the preference for sweet and alcohol". Endocrine Abstracts. 56. doi:10.1530/endoabs.56.S2.3.
  14. ^ a b Hwang, Liang-Dar (2019). "New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances". The American Journal of Clinical Nutrition. 109 (6): 1724–1737. doi:10.1093/ajcn/nqz043. PMC 6537940. PMID 31005972.
  15. ^ a b Sevgi, Meltem; Rigoux, Lionel; Kuhn, Anne; Mauer, Jan; Schilbach, Leonhard; Hess, Martin; Gruendler, Theo; Ullsperger, Markus; Stephan, Klaas Enno; Bruning, Jess; Tittgemeyer, Marc (2015). "An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning". Journal of Neuroscience. 35 (36): 12584–12592. doi:10.1523/JNEUROSCI.1589-15.2015. PMC 6605390. PMID 26354923.
  16. ^ Keskitalo, Kaisu; Knaapila, Antti; Kallela, Mikko; Palotie, Aarno; Wessman, Maija; Sammalisto, Sampo; Peltonen, Leena; Tuorila, Hely; Perola, Markus (2007). "Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16". The American Journal of Clinical Nutrition. 86 (1): 55–63. doi:10.1093/ajcn/86.1.55. PMID 17616763.
  17. ^ a b Fortuna, Jeffrey (2010). "Sweet Preference, Sugar Addiction and the Familial History of Alcohol Dependence: Shared Neural Pathways and Genes". Journal of Psychoactive Drugs. 42 (2): 147–151. doi:10.1080/02791072.2010.10400687. PMID 20648910. S2CID 24286898.
  18. ^ a b c d Diac, Anemari Emanuela; Constantinescu, Natalia (2017). "Self-compassion, Well-being and Chocolate Addiction" (PDF). Romanian Journal of Cognitive Behavioral Therapy and Hypnosis. 4 (1–2): 2–10.
  19. ^ a b c d Gibson, E.L. (2011). "Emotional and Behavioral Aspects of Chocolate Eating". In Victor R. Preedy; Ronald Ross Watson; Colin R. Martin (eds.). Handbook of Behavior, Food and Nutrition. pp. 601–620. doi:10.1007/978-0-387-92271-3_40. ISBN 978-0-387-92270-6.
  20. ^ Roxby, Philippa (2013). "Chocolate craving comes from total sensory pleasure". BBC News. Retrieved April 20, 2020.
  21. ^ Robson, Anthony (2012). "Chocolate Bars Based on Human Nutritional Requirements". Chocolate in Health and Nutrition. Vol. 7. pp. 143–148. doi:10.1007/978-1-61779-803-0_12. ISBN 978-1-61779-802-3.
  22. ^ "Bad News: The Sugar Cravings Around Your Period Are Actually Ageing You". huffingtonpost.co.uk. 11 July 2014. Retrieved 3 April 2018.
  23. ^ a b c d e Seidenberg, Casey (2018). "Why We Crave Sugar and How to Beat the Habit". The Washington Post. Retrieved March 23, 2020.
  24. ^ Skarnulis, Leanna (February 4, 2005). "The Chocoholic's Survival Guide". WebMD. Retrieved 14 April 2013.
  25. ^ "'Chocoholism' may be a cultural phenomenon for women". CNN. 15 February 1999.
  26. ^ a b c d e Nehlig, Astrid (2013). "The neuroprotective effects of cocoa flavanol and its influence on cognitive performance". British Journal of Clinical Pharmacology. 75 (3): 716–727. doi:10.1111/j.1365-2125.2012.04378.x. PMC 3575938. PMID 22775434.
  27. ^ Westwater, Margaret L; Fletcher, Paul C; Ziauddeen, Hisham (2016). "Sugar addiction: the state of the science". European Journal of Nutrition. 55 (1): 55–69. doi:10.1007/s00394-016-1229-6. PMC 5174153. PMID 27372453.
  28. ^ Conway, Jonathan (25 August 2017). "What do your food cravings say about you?". Chronicle–Herald. Halifax. p. D6. ProQuest 1932368907.
  29. ^ Martin, Corby K.; McClernon, F. Joseph; Chellino, Anastasia; Correa, John B. (2011). "Food Cravings: A Central Construct in Food Intake Behavior, Weight Loss, and the Neurobiology of Appetitive Behavior". In Victor R. Preedy; Ronald Ross Watson; Colin R. Martin (eds.). Handbook of Behavior, Food and Nutrition. pp. 741–755. doi:10.1007/978-0-387-92271-3_49. ISBN 978-0-387-92270-6.
  30. ^ Greer, Stephanie M.; Goldstein, Andrea N.; Walker, Matthew P. (2013). "The impact of sleep deprivation on food desire in the human brain". Nature Communications. 4: 2259. Bibcode:2013NatCo...4.2259G. doi:10.1038/ncomms3259. PMC 3763921. PMID 23922121.
  31. ^ Yang, Qing (2010). "Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings". Yale Journal of Biology and Medicine. 83 (2): 101–108. PMC 2892765. PMID 20589192.
  32. ^ Strawbridge, Holly (2012). "Artificial sweeteners: sugar-free, but at what cost?". Harvard Health. Retrieved May 19, 2020.
  33. ^ Bruce, Debra Fulghum. "Cinnamon and Diabetes". WebMD.
  34. ^ Craig, Winston J.; Nguyen, Thuy T. (1984). "Caffeine and Theobromine Levels in Cocoa and Carob Products". Journal of Food Science. 49 (1): 302–303. doi:10.1111/j.1365-2621.1984.tb13737.x.
  35. ^ "FoodData Central". fdc.nal.usda.gov.
  36. ^ a b c d Rodrigues-Silva, Nuno (2013). "Chocolate: Psychopharmacological Aspects, Mood, and Addiction". Chocolate in Health and Nutrition. Vol. 7. pp. 421–435. doi:10.1007/978-1-61779-803-0_31. ISBN 978-1-61779-802-3.
  37. ^ a b Cotton, Simon (2014). "Why chocolate really is the secret to happiness". The Washington Post. Retrieved May 18, 2020.
  38. ^ James, J.S. (1996). "Marijuana and Chocolate". AIDS Treatment News. 257 (257): 3–4. PMID 11363932.
  39. ^ a b c d "FoodData Central". fdc.nal.usda.gov.
  40. ^ (Handbook of Experimental Pharmacology 200) Bertil B. Fredholm (auth.) - Methylxanthines-Springer-Verlag Berlin Heidelberg (2011), page 2014
  41. ^ a b "Chocoholic? Now for the science part". Wales Online. April 18, 2006. Retrieved 14 April 2013.
  42. ^ Sokolov, Alexander; Pavlova, Marina; Klosterhalfen, Sibylle; Enck, Paul (2013). "Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behaviour". Neuroscience and Biobehavioral Reviews. 37 (10): 2445–2453. doi:10.1016/j.neubiorev.2013.06.013. PMID 23810791. S2CID 17371625.
  43. ^ Melzig, Matthias F.; Putscher, Ingo; Henklein, Petra; Haber, Hanka (2000). "In vitro pharmacological activity of thetetrahydroisoquinoline salsolinol present in products from Theobroma cacao L. like cocoa and chocolate". Journal of Ethnopharmacology. 73 (1–2): 153–159. doi:10.1016/S0378-8741(00)00291-9. PMID 11025151 – via Elsevier Science Direct.
  44. ^ Bardin, Jon (2012). "Craving chocolate? Activity in certain brain area might be why". Los Angeles Times. Retrieved April 28, 2020.
  45. ^ Cinquanta, L. (2016). "Mineral essential elements for nutrition in different chocolate products". International Journal of Food Sciences and Nutrition. 67 (7): 773–778. doi:10.1080/09637486.2016.1199664. PMID 27346251. S2CID 41950395.
  46. ^ Spector, Nicole (2020). "Why chocolate is so addicting and how to tap into the health benefits". NBC News. Retrieved May 1, 2020.
  47. ^ De Clercq, Nathalie (2011). Changing the functionality of cocoa butter. PhD Thesis, Ghent University, Belgium. pp. 163–164. ISBN 978-90-5989-470-9.
  48. ^ Aprotosoaie, Ana Clara; Luca, Simon Vlad; Miron, Anca (2015). "Flavor Chemistry of Cocoa and Cocoa Products—An Overview". Comprehensive Reviews in Food Science and Food Safety. 15 (1): 74–87. doi:10.1111/1541-4337.12180. PMID 33371573.
  49. ^ Rowat, Amy C.; Hollar, Kathryn A.; Stone, Howard A.; Rosenberg, Daniel (2010). "The Science of Chocolate: Interactive Activities on Phase Transitions, Emulsification, and Nucleation". Journal of Chemical Education. 88 (1): 29–33. doi:10.1021/ed100503p.
  50. ^ Lippi, Donatella (2013). "Chocolate in History: Food, Medicine, Medi-Food". Nutrients. 5 (5): 1573–1584. doi:10.3390/nu5051573. PMC 3708337. PMID 23673608.
  51. ^ a b c d Grivetti, Louis. "From Aphrodisiac to Health Food: A Cultural History of Chocolate". Karger Gazette. Retrieved March 21, 2020.
  52. ^ O'Connor, Anahad (2006). "The Claim: Chocolate Is an Aphrodisiac". The New York Times. Retrieved March 29, 2020.
  53. ^ Felson, Sabrina (2020). "The History of Chocolate Slideshow". WebMD. Retrieved May 27, 2020.
  54. ^ a b Weinberg, Bennett Alan; Bealer, Bonnie K (2001). The World of Caffeine: The Science and Culture of the World's Most Popular Drug. London: Psychology Press. pp. 53–61. ISBN 0415927226.
  55. ^ a b Lippi, Donatella; Watson, Ronald Ross; Preedy, Victor R.; Zibadi, Sherma (2012). "History of the Medical Use of Chocolate". Chocolate in Health and Nutrition. Totowa, NJ, United States: Humana Press. pp. 11–15. ISBN 9781617798023.
  56. ^ a b Dillinger, Teresa L; Barriga, Patricia; Escárcega, Sylvia; Jimenez, Martha; Salazar-Lowe, Diana Salazar; Grivetti, Louis (2000). "Food of the Gods: Cure for Humanity? A Cultural History of the Medicinal and Ritual Use of Chocolate". The Journal of Nutrition. 130 (8): 2057S–2072S. doi:10.1093/jn/130.8.2057S. PMID 10917925.
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