In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction
| chlordecone reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| EC no. | 1.1.1.225 | ||||||||
| CAS no. | 102484-73-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- chlordecone alcohol + NADP+ chlordecone + NADPH + H+
Thus, the two substrates of this enzyme are chlordecone alcohol and NADP+, whereas its 3 products are chlordecone, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR.
Structural studies
editAs of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FVL.
References
edit- Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. Biol. Chem. 261 (27): 12624–7. doi:10.1016/S0021-9258(18)67136-4. PMID 2427522.
