Caprin-1

Caprin-1 is a protein that in humans is encoded by the CAPRIN1 gene. It is suggested that Caprin1 (a.k.a. RNG105) is essential for the formation of long-term memory.

CAPRIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WBE, 4WBP
Identifiers
Aliases	CAPRIN1, GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI, cell cycle associated protein 1
External IDs	OMIM: 601178; MGI: 1858234; HomoloGene: 4310; GeneCards: CAPRIN1; OMA:CAPRIN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p13 Start 34,051,731 bp End 34,102,610 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E2 Start 103,593,286 bp End 103,627,994 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone Achilles tendon islet of Langerhans endometrium left testis epithelium of colon right testis stromal cell of endometrium gonad Top expressed in genital tubercle tail of embryo ureter primitive streak maxillary prominence abdominal wall external carotid artery internal carotid artery mandibular prominence medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasmic stress granule dendrite P-body integral component of plasma membrane cell projection membrane cytoplasm cytosol synapse Biological process cell differentiation negative regulation of translation positive regulation of dendrite morphogenesis positive regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4076 53872 Ensembl ENSG00000135387 ENSMUSG00000027184 UniProt Q14444 Q60865 RefSeq (mRNA) NM_005898 NM_203364 NM_001111289 NM_001111290 NM_001111291 NM_001111292 NM_016739 RefSeq (protein) NP_005889 NP_976240 NP_001104759 NP_001104760 NP_001104761 NP_001104762 NP_058019 Location (UCSC) Chr 11: 34.05 – 34.1 Mb Chr 2: 103.59 – 103.63 Mb PubMed search
Wikidata
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Clinical significance

In 2022, loss-of-function mutations of the CAPRIN1 gene were shown to result in an autosomal-dominant disorder. Patients having the newly-discovered disorder suffer from language impairment, speech delay, intellectual disability, ADHD and autism spectrum disorder. Somatically, they have respiratory problems, limb/skeletal anomalies, developmental delay, feeding difficulties, seizures and ophthalmologic problems.

Further reading

• Gessler M, Klamt B, Tsaoussidou S, Ellis JA, Luzio JP (February 1996). "The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse". Genomics. 32 (1): 169–70. doi:10.1006/geno.1996.0099. PMID 8786113.
• de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W (November 2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". The EMBO Journal. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.