Caffeate 3,4-dioxygenase

Caffeate 3,4-dioxygenase (EC 1.13.11.22) is an enzyme that catalyzes the chemical reaction

caffeate 3,4-dioxygenase
Identifiers
EC no.	1.13.11.22
CAS no.	37256-61-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

3,4-dihydroxy-trans-cinnamate + O₂ $\rightleftharpoons$ 3-(2-carboxyethenyl)-cis,cis-muconate

Thus, the two substrates of this enzyme are 3,4-dihydroxy-trans-cinnamate (caffeic acid) and oxygen, whereas its product is 3-(2-carboxyethenyl)-cis,cis-muconate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing). This enzyme participates in phenylpropanoid biodegradation.

References

• Seidman MM, Toms A, Wood JM (1969). "Influence of side-chain substituents on the position of cleavage of the benzene ring by Pseudomonas fluorescens". J. Bacteriol. 97 (3): 1192–7. doi:10.1128/jb.97.3.1192-1197.1969. PMC 249834. PMID 5776526.