Cyp6g1 or DDT-R is an insecticide resistance gene for resistance to DDT in Drosophila melanogaster.[1] It belongs to the cytochrome P450 family and is located in chromosome 2R.[2] Following up their earlier work, Daborn et al. 2002 find the DDT-R gene induces overtranscription of Cyp6g1, of which there are 4 duplicates.[3] They also find several substrates of Cyp6g1, namely DDT, lufenuron, and nitenpyram.[3]
| Cytochrome P450 6g1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Cyp6g1 | ||||||
| Alt. symbols | CYP6-like, DDT-R, Rst(2)DDT | ||||||
| Entrez | 36316 | ||||||
| HomoloGene | 59722 | ||||||
| RefSeq (mRNA) | NM_136899.4 | ||||||
| RefSeq (Prot) | NP_610743.2 | ||||||
| UniProt | Q9V674 | ||||||
| Other data | |||||||
| EC number | 1.14.-.- | ||||||
| Chromosome | 2R: 12.19 - 12.19 Mb | ||||||
| |||||||
References
edit- ^ McCart C, ffrench-Constant RH (June 2008). "Dissecting the insecticide-resistance- associated cytochrome P450 gene Cyp6g1". Pest Management Science. 64 (6): 639–645. doi:10.1002/ps.1567. PMID 18338338.
- ^ Le Goff G, Hilliou F (March 2017). "Resistance evolution in Drosophila: the case of CYP6G1". Pest Management Science. 73 (3): 493–499. doi:10.1002/ps.4470. PMID 27787942.
- ^ a b Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, et al. (Drosophila 12 Genomes Consortium) (November 2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167). Nature Portfolio: 203–218. Bibcode:2007Natur.450..203C. doi:10.1038/nature06341. PMID 17994087. S2CID 2416812.
External links
edit- FlyBase Gene Report: Dmel\Cyp6g1 at FlyBase database of Drosophila genes.
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