Cystatin-F is a protein that in humans is encoded by the CST7 gene.[5][6][7]

CST7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCST7, CMAP, cystatin F
External IDsOMIM: 603253; MGI: 1298217; HomoloGene: 37832; GeneCards: CST7; OMA:CST7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003650

NM_009977

RefSeq (protein)

NP_003641

NP_034107

Location (UCSC)Chr 20: 24.95 – 24.96 MbChr 2: 150.41 – 150.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000077984Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068129Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ni J, Fernandez MA, Danielsson L, Chillakuru RA, Zhang J, Grubb A, Su J, Gentz R, Abrahamson M (Oct 1998). "Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor". J Biol Chem. 273 (38): 24797–804. doi:10.1074/jbc.273.38.24797. PMID 9733783.
  6. ^ Halfon S, Ford J, Foster J, Dowling L, Lucian L, Sterling M, Xu Y, Weiss M, Ikeda M, Liggett D, Helms A, Caux C, Lebecque S, Hannum C, Menon S, McClanahan T, Gorman D, Zurawski G (Aug 1998). "Leukocystatin, a new Class II cystatin expressed selectively by hematopoietic cells". J Biol Chem. 273 (26): 16400–8. doi:10.1074/jbc.273.26.16400. PMID 9632704.
  7. ^ a b "Entrez Gene: CST7 cystatin F (leukocystatin)".

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Further reading

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