Cystatin-M is a protein that in humans is encoded by the CST6 gene.[5][6][7]

CST6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCST6, cystatin E/M, ECTD15
External IDsOMIM: 601891; MGI: 1920970; HomoloGene: 1011; GeneCards: CST6; OMA:CST6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001323

NM_028623

RefSeq (protein)

NP_001314

NP_082899

Location (UCSC)Chr 11: 66.01 – 66.01 MbChr 19: 5.39 – 5.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175315Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024846Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stenman G, Astrom AK, Roijer E, Sotiropoulou G, Zhang M, Sager R (Jun 1997). "Assignment of a novel cysteine proteinase inhibitor (CST6) to 11q13 by fluorescence in situ hybridization". Cytogenet Cell Genet. 76 (1–2): 45–6. doi:10.1159/000134512. PMID 9154125.
  6. ^ Ni J, Abrahamson M, Zhang M, Fernandez MA, Grubb A, Su J, Yu GL, Li Y, Parmelee D, Xing L, Coleman TA, Gentz S, Thotakura R, Nguyen N, Hesselberg M, Gentz R (May 1997). "Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins". J Biol Chem. 272 (16): 10853–8. doi:10.1074/jbc.272.16.10853. PMID 9099741.
  7. ^ a b "Entrez Gene: CST6 cystatin E/M".
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Further reading

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