COG8

Conserved oligomeric Golgi complex subunit 8 is a protein that in humans is encoded by the COG8 gene.

COG8
Identifiers
Aliases	COG8, CDG2H, DOR1, component of oligomeric golgi complex 8
External IDs	OMIM: 606979; MGI: 2142885; HomoloGene: 13018; GeneCards: COG8; OMA:COG8 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 69,320,140 bp End 69,339,667 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 107,772,921 bp End 107,783,321 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm tibialis anterior muscle stromal cell of endometrium gastrocnemius muscle mucosa of ileum right adrenal gland cerebellar vermis right adrenal cortex muscle of thigh left adrenal gland Top expressed in otic vesicle saccule seminiferous tubule otic placode spermatid spermatocyte muscle of thigh granulocyte interventricular septum right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component membrane Golgi transport complex trans-Golgi network membrane Golgi membrane Golgi apparatus Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84342 97484 Ensembl ENSG00000213380 ENSMUSG00000031916 UniProt Q96MW5 Q9JJA2 RefSeq (mRNA) NM_032382 NM_001374871 NM_139229 RefSeq (protein) NP_115758 NP_631975 Location (UCSC) Chr 16: 69.32 – 69.34 Mb Chr 8: 107.77 – 107.78 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi complex (COG), which includes COG8 (Ungar et al., 2002).[supplied by OMIM]

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II". J. Cell Biol. 152 (1): 75–85. doi:10.1083/jcb.152.1.75. PMC 2193649. PMID 11149922.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
• Whyte JR, Munro S (2001). "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic". Dev. Cell. 1 (4): 527–37. doi:10.1016/S1534-5807(01)00063-6. PMID 11703943.
• Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
• Human COG8 genome location and COG8 gene details page in the UCSC Genome Browser.