CLDN19

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.

CLDN19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3X29
Identifiers
Aliases	CLDN19, HOMG5, claudin 19
External IDs	OMIM: 610036; MGI: 3033992; HomoloGene: 17528; GeneCards: CLDN19; OMA:CLDN19 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 42,733,093 bp End 42,740,254 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.1 Start 119,112,611 bp End 119,119,635 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion spinal ganglia retinal pigment epithelium renal medulla tibial nerve vena cava epithelium of nasopharynx body of tongue ventral tegmental area trachea Top expressed in sciatic nerve right kidney inner renal medulla outer renal medulla spinal ganglia lip human kidney lens embryo muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity identical protein binding protein binding Cellular component cytoplasm integral component of membrane cell junction plasma membrane basolateral plasma membrane apical junction complex nucleus bicellular tight junction membrane Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules apical junction assembly neuronal action potential propagation response to stimulus visual perception tight junction organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 149461 242653 Ensembl ENSG00000164007 ENSMUSG00000066058 UniProt Q8N6F1 Q9ET38 RefSeq (mRNA) NM_148960 NM_001123395 NM_001185117 NM_001038590 NM_153105 RefSeq (protein) NP_001116867 NP_001172046 NP_683763 NP_001033679 NP_694745 Location (UCSC) Chr 1: 42.73 – 42.74 Mb Chr 4: 119.11 – 119.12 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM]

External links

• Human CLDN19 genome location and CLDN19 gene details page in the UCSC Genome Browser.

Further reading

• Kniesel U, Wolburg H (February 2000). "Tight junctions of the blood-brain barrier". Cellular and Molecular Neurobiology. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
• Heiskala M, Peterson PA, Yang Y (February 2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–98. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
• Tsukita S, Furuse M, Itoh M (April 2001). "Multifunctional strands in tight junctions". Nature Reviews. Molecular Cell Biology. 2 (4): 285–293. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
• Tsukita S, Furuse M (October 2002). "Claudin-based barrier in simple and stratified cellular sheets". Current Opinion in Cell Biology. 14 (5): 531–536. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (January 2003). "Tight junction proteins". Progress in Biophysics and Molecular Biology. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Lee NP, Tong MK, Leung PP, Chan VW, Leung S, Tam PC, et al. (February 2006). "Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease". FEBS Letters. 580 (3): 923–931. Bibcode:2006FEBSL.580..923L. doi:10.1016/j.febslet.2006.01.019. PMID 16427635. S2CID 21297265.
• Konrad M, Schaller A, Seelow D, Pandey AV, Waldegger S, Lesslauer A, et al. (November 2006). "Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement". American Journal of Human Genetics. 79 (5): 949–957. doi:10.1086/508617. PMC 1698561. PMID 17033971.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, et al. (February 2016). "Systems Proteomics View of the Endogenous Human Claudin Protein Family". Journal of Proteome Research. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.