Wikipedia

CDKN2B

Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans.[5][6]

CDKN2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B
External IDsOMIM: 600431; MGI: 104737; HomoloGene: 55859; GeneCards: CDKN2B; OMA:CDKN2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1030

12579

Ensembl

ENSG00000147883

ENSMUSG00000073802

UniProt

P42772

P55271

RefSeq (mRNA)

NM_078487
NM_004936

NM_007670

RefSeq (protein)

NP_004927
NP_511042

NP_031696

Location (UCSC)Chr 9: 22 – 22.01 MbChr 4: 89.22 – 89.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated, deleted, or disregulated in a wide variety of cancer.[7][8][9] This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcripts of this gene encode proteins that share the N-terminal sequence but completely differ in the C-terminus.[6]

Interactions

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CDKN2B tumor suppressor gene product p15 has been shown to interact with cyclin-dependent kinase 4.[10][11]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147883 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073802 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hannon GJ, Beach D (September 1994). "p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest". Nature. 371 (6494): 257–61. Bibcode:1994Natur.371..257H. doi:10.1038/371257a0. PMID 8078588. S2CID 4268054.
  6. ^ a b "Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)".
  7. ^ Tu Q, Hao J, Zhou X, Yan L, Dai H, Sun B, et al. (January 2018). "CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A". Oncogene. 37 (1): 128–138. doi:10.1038/onc.2017.316. PMC 5759028. PMID 28892048.
  8. ^ Jafri M, Wake NC, Ascher DB, Pires DE, Gentle D, Morris MR, et al. (July 2015). "Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma". Cancer Discovery. 5 (7): 723–9. doi:10.1158/2159-8290.CD-14-1096. PMID 25873077.
  9. ^ Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H (January 2008). "Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA". Nature. 451 (7175): 202–6. Bibcode:2008Natur.451..202Y. doi:10.1038/nature06468. PMC 2743558. PMID 18185590.
  10. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  11. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

Further reading

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