Wikipedia

Biomedical Research Center

The Biomedical Research Center (BRC) is a research center at Qatar University focusing on biomedical research. BRC was founded in 2014, and partners with the Ministry of Public Health (Qatar), and Hamad Medical Corporation (HMC).[1][2][3]

History

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The incidence of genetic disorders in Qatar is high,[4] with the top three causes of death in the country being cancer, heart diseases, and diabetes.[5][6] The government saw the creation of BRC as a strategy for proactively preventing diseases to help foster public health.[7][8]

BRC labs received the ISO/IEC - 17025 accreditation from the American Association for Laboratory Accreditation (A2LA).[9] This research center focus on infectious diseases (virology and microbiology), metabolic disorders, and biomedical omics.[10]

Research

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Since its establishment in 2014, the BRC has published over 530 research papers.[11][12] The centre's research projects encompass a range of areas, including:

  1. Antibiotic profiling of antibiotic-resistant microbes in humans and animals.[13][14][15][16][17]
  2. Investigating variations in cases of type 2 diabetes.[18][19]
  3. Studying COVID-19,[20][21][22][23][24][25][26][27][28] including the Omicron variant.[29][30][31]
  4. Conducting genetic sequencing of Qatari falcons,[27][28] endangered animal species,[32] and the dugong.[27][28]
  5. Exploring nanomedicine as a means of disease prevention.[33][34][35]

Zebrafish Research Model

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BRC Introduced the use of zebrafish as an animal model in biomedical research at Qatar University

BRC Introduced the use of zebrafish as an animal model in biomedical research[36][37][32][38][39][40] and established a facility for it in 2015.[41][42][43] The facility is used as a research unit to study many genetic diseases.[32] The Ministry of Public Health articulated an institutional research policy (IRP) on the use of zebrafish in research,[44] which Qatar University backed.

Facilities

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Biosafety level 3 (BSL3) lab at BRC, Qatar University

The BRC facilities include:[41]

See also

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References

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  1. ^ "BRC AND SCH SIGN COLLABORATIVE AGREEMENT". www.qu.edu.qa. 2015-11-05.
  2. ^ "Biomedical Research Center | Qatar University". www.qu.edu.qa. 2023.
  3. ^ "Qatar puts the pursuit of knowledge front and centre". 2023.
  4. ^ "Research | Qatar Genome Programme". www.qatargenome.org.qa. 2023.
  5. ^ "Qatar". Institute for Health Metrics and Evaluation. 2015-09-09.
  6. ^ "Health and Biomedical Sciences". Qatar University. 2020-10-19.
  7. ^ "Qatar National Vision 2030 | General Secretariat For Development Planning" (PDF). July 2008.
  8. ^ "Research Pillars and Priorities | Qatar University". www.qu.edu.qa. 2020-10-19.
  9. ^ "QU BIOMEDICAL RESEARCH CENTER AND LABORATORY ANIMAL RESEARCH CENTER AWARDED ISO IEC - 17025 ACCREDITATION". www.qu.edu.qa. 2018-07-01.
  10. ^ "Divisions and Researches | Qatar University". www.qu.edu.qa. Retrieved 2023-03-14.
  11. ^ "BRC Publications". Qatar University. 2022-02-24.
  12. ^ "Qatar University Institutional Repository | Biomedical Research Center". qspace.qu.edu.qa. 2023.
  13. ^ El Zowalaty ME, Al Thani AA, Webster TJ, El Zowalaty AE, Schweizer HP, Nasrallah GK, et al. (2015-10-01). "Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies". Future Microbiology. 10 (10): 1683–1706. doi:10.2217/fmb.15.48. PMID 26439366.
  14. ^ Johar AR, Abu-Rub LI, Al Mana H, Yassine HM, Eltai NO (September 2022). "Microbiome engineering to combat antimicrobial resistance and upsurge productivity of food animals: a systematic review". Animal Production Science. 63 (2): 101–112. doi:10.1071/AN22233. hdl:10576/34433. S2CID 252257034.
  15. ^ Eltai NO, Yassine HM, Al Thani AA, Abu Madi MA, Ismail A, Ibrahim E, Alali WQ (2018). "Prevalence of antibiotic resistant Escherichia coli isolates from fecal samples of food handlers in Qatar". Antimicrobial Resistance and Infection Control. 7: 78. doi:10.1186/s13756-018-0369-2. PMC 6019201. PMID 29983931.
  16. ^ Al-Hadidi SH, Al Mana H, Almoghrabi SZ, El-Obeid T, AlAli WQ, Eltai NO (July 2022). "Retail Chicken Carcasses as a Reservoir of Multidrug-Resistant Salmonella". Microbial Drug Resistance. 28 (7). Larchmont, N.Y.: 824–831. doi:10.1089/mdr.2021.0414. PMC 9347385. PMID 35675669.
  17. ^ a b "Qatar University's Biomedical Research Center conducting research on COVID-19". The Peninsula Newspaper. 2020-03-29. Retrieved 2023-03-14.
  18. ^ Al-Sulaiti H, Diboun I, Agha MV, Mohamed FF, Atkin S, Dömling AS, et al. (October 2019). "Metabolic signature of obesity-associated insulin resistance and type 2 diabetes". Journal of Translational Medicine. 17 (1): 348. doi:10.1186/s12967-019-2096-8. PMC 6805293. PMID 31640727.
  19. ^ "WCM-Q research probes causal link between obesity and diabetes". Latest News - Weill Cornell Medicine - Qatar. December 2019.
  20. ^ Wang L, Shi W, Joyce MG, Modjarrad K, Zhang Y, Leung K, et al. (July 2015). "Evaluation of candidate vaccine approaches for MERS-CoV". Nature Communications. 6 (1): 7712. Bibcode:2015NatCo...6.7712W. doi:10.1038/ncomms8712. PMC 4525294. PMID 26218507.
  21. ^ Chemaitelly H, Yassine HM, Benslimane FM, Al Khatib HA, Tang P, Hasan MR, et al. (September 2021). "mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar" (PDF). Nature Medicine. 27 (9): 1614–1621. doi:10.1038/s41591-021-01446-y. PMID 34244681. S2CID 235786967.
  22. ^ Tang P, Hasan MR, Chemaitelly H, Yassine HM, Benslimane FM, Al Khatib HA, et al. (December 2021). "BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar". Nature Medicine. 27 (12): 2136–2143. doi:10.1038/s41591-021-01583-4. hdl:10576/24856. PMID 34728831. S2CID 241108406.
  23. ^ Younes N, Al-Sadeq DW, Al-Jighefee H, Younes S, Al-Jamal O, Daas HI, et al. (May 2020). "Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2". Viruses. 12 (6): 582. doi:10.3390/v12060582. PMC 7354519. PMID 32466458.
  24. ^ Chemaitelly H, Tang P, Hasan MR, AlMukdad S, Yassine HM, Benslimane FM, et al. (December 2021). "Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar". The New England Journal of Medicine. 385 (24): e83. doi:10.1056/NEJMoa2114114. PMC 8522799. PMID 34614327.
  25. ^ Abu-Raddad LJ, Chemaitelly H, Butt AA (July 2021). "Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants". The New England Journal of Medicine. 385 (2): 187–189. doi:10.1056/NEJMc2104974. PMC 8117967. PMID 33951357.
  26. ^ "(BRC)- (QU) CONDUCTS SIX RESEARCH PROJECTS ON COVID-19". www.qu.edu.qa. Retrieved 2020-03-28.
  27. ^ a b c "Qatar University's Biomedical Research Center conducting research on COVID-19". The Peninsula Newspaper. 2020-03-29.
  28. ^ a b c d "Qatar- QU conducts research on coronavirus". MENAFN.COM. 2020-03-28.
  29. ^ Altarawneh HN, Chemaitelly H, Hasan MR, Ayoub HH, Qassim S, AlMukdad S, et al. (March 2022). "Protection against the Omicron Variant from Previous SARS-CoV-2 Infection". The New England Journal of Medicine. 386 (13): 1288–1290. doi:10.1056/NEJMc2200133. PMC 8849180. PMID 35139269.
  30. ^ Abu-Raddad LJ, Chemaitelly H, Ayoub HH, AlMukdad S, Yassine HM, Al-Khatib HA, et al. (May 2022). "Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar". The New England Journal of Medicine. 386 (19): 1804–1816. doi:10.1056/NEJMoa2200797. PMC 8929389. PMID 35263534.
  31. ^ Altarawneh HN, Chemaitelly H, Ayoub HH, Tang P, Hasan MR, Yassine HM, et al. (July 2022). "Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections". The New England Journal of Medicine. 387 (1): 21–34. doi:10.1056/NEJMoa2203965. PMC 9258753. PMID 35704396.
  32. ^ a b c d "Qatar- QUBRC records rapid growth in published medical resea... | MENAFN.COM". menafn.com. 2020-11-27.
  33. ^ Mohamed NA, Zupin L, Mazi SI, Al-Khatib HA, Crovella S (February 2023). "Nanomedicine as a Potential Tool against Monkeypox". Vaccines. 11 (2): 428. doi:10.3390/vaccines11020428. PMC 9963669. PMID 36851305.
  34. ^ Mohamed NA, Abou-Saleh H, Mohamed HA, Al-Ghouti MA, Crovella S, Zupin L (July 2022). "Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2". Viruses. 14 (7): 1553. doi:10.3390/v14071553. PMC 9318803. PMID 35891532.
  35. ^ Mohamed NA, Marei I, Crovella S, Abou-Saleh H (January 2022). "Recent Developments in Nanomaterials-Based Drug Delivery and Upgrading Treatment of Cardiovascular Diseases". International Journal of Molecular Sciences. 23 (3): 1404. doi:10.3390/ijms23031404. PMC 8836006. PMID 35163328.
  36. ^ Zakaria ZZ, Benslimane FM, Nasrallah GK, Shurbaji S, Younes NN, Mraiche F, et al. (2018-09-27). "Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity". BioMed Research International. 2018: 1642684. doi:10.1155/2018/1642684. PMC 6180974. PMID 30363733.
  37. ^ Yalcin HC, Benslimane FM, Kawakami K (October 2019). "The First International Zebrafish Conference/Workshop in Qatar". Zebrafish. 16 (5): 493–495. doi:10.1089/zeb.2019.1786. PMID 31453757. S2CID 201731365.
  38. ^ "Utilization Of Zebrafish As An Animal Model". Qatar University. August 2021.
  39. ^ "Qatar International Zebrafish Workshop". Qatar University. April 2017.
  40. ^ "Qatar University workshop introduces 'zebrafish model' research". The Peninsula Newspaper. 2019-04-20.
  41. ^ a b "Facilities". Qatar University. 2023.
  42. ^ "QU Paves the Way in Research in Zebra Fish". www.qu.edu.qa. 2019-04-14.
  43. ^ "The First International Zebrafish Conference/Workshop in Qatar | IZFS - International Zebrafish Society". www.izfs.org. 2019.
  44. ^ "Policy on Zebrafish Research, Ministry of Public Health, Department of Research Regulation" (PDF). 2020.
  45. ^ "Certek, biosafety laboratory, custom built modular laboratories, modular laboratory, biosafety, BSL-3". CERTEK. Retrieved 2023-03-15.
  46. ^ Al Khatib HA, Mathew S, Smatti MK, Eltai NO, Pathan SA, Al Thani AA, et al. (June 2021). "Profiling of Intestinal Microbiota in Patients Infected with Respiratory Influenza A and B Viruses". Pathogens. 10 (6): 761. doi:10.3390/pathogens10060761. PMC 8233933. PMID 34204203.
  47. ^ Al Mana H, Sundararaju S, Tsui CK, Perez-Lopez A, Yassine H, Al Thani A, et al. (August 2021). "Whole-Genome Sequencing for Molecular Characterization of Carbapenem-Resistant Enterobacteriaceae Causing Lower Urinary Tract Infection among Pediatric Patients". Antibiotics. 10 (8): 972. doi:10.3390/antibiotics10080972. PMC 8388976. PMID 34439022.
  48. ^ Boughattas S, Albatesh D, Al-Khater A, Giraldes BW, Althani AA, Benslimane FM (December 2021). "Whole genome sequencing of marine organisms by Oxford Nanopore Technologies: Assessment and optimization of HMW-DNA extraction protocols". Ecology and Evolution. 11 (24): 18505–18513. Bibcode:2021EcoEv..1118505B. doi:10.1002/ece3.8447. PMC 8717308. PMID 35003688.
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