Beta-cyclopiazonate dehydrogenase

Beta-cyclopiazonate dehydrogenase (EC 1.21.99.1) is an enzyme that catalyzes the chemical reaction

beta-cyclopiazonate dehydrogenase
Identifiers
EC no.1.21.99.1
CAS no.9059-00-1
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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Gene OntologyAmiGO / QuickGO
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beta-cyclopiazonate + acceptor alpha-cyclopiazonate + reduced acceptor

Thus, the two substrates of this enzyme are beta-cyclopiazonate and an acceptor, whereas its two products are alpha-cyclopiazonate and a reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on X-H and Y-H to form an X-Y bond with other acceptors. The systematic name of this enzyme class is beta-cyclopiazonate:acceptor oxidoreductase (cyclizing). Other names in common use include beta-cyclopiazonate oxidocyclase, beta-cyclopiazonic oxidocyclase, and beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing). It employs one cofactor, FAD.

References

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  • Edmondson DE, Kenney WC, Singer TP (1976). "Structural elucidation and properties of 8alpha-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and beta-cyclopiazonate oxidocyclase". Biochemistry. 15 (14): 2937–45. doi:10.1021/bi00659a001. PMID 8076.
  • Schabort JC, Potgeiter DJ (1971). "-cyclopiazonate oxidocyclase from Penicillium cyclopium. II. Studies on electron acceptors, inhibitors, enzyme kinetics, amino acid composition, flavin prosthetic group and other properties". Biochim. Biophys. Acta. 250 (2): 329–45. doi:10.1016/0005-2744(71)90189-6. PMID 5143340.