Barbara Illingworth Brown was an American biochemist. She worked primarily at Washington University in St. Louis.
Barbara Illingworth Brown | |
|---|---|
| Born | Barbara A. Illingworth May 12, 1924[1] Hartford, CT |
| Died | September 27, 2016[1] |
| Alma mater | Yale University |
| Scientific career | |
| Thesis | Effects of purified growth hormone on glycogen storage (1950) |
| Doctoral advisor | Jane Anne Russell |
Education and career
editBrown was born in Hartford, Connecticut and later moved to Pennsylvania when her father's job in insurance moved the family.[2] Brown graduated from Smith College in 1946. She worked with Jane Anne Russell at Yale University[2] and received her PhD in physiological chemistry in 1950.[3][4] Following her Ph.D., Brown applied to work with the Nobel Prize-winner Gerty Cori[2] and became a Research Associate Professor of Biochemistry at Washington University in St. Louis and Established Investigator of the American Heart Association.[5] She later also worked with Cori's husband and fellow Nobel Prize winner Carl Ferdinand Cori.[2] She retired in 1989.[2]
Brown served on the National Advisory General Medical Sciences Council at the National Institutes of Health from 1972 to 1974.[6] She was awarded the Wilbur Cross Medal from Yale in 1983.[7]
Research
editHer work was primarily devoted to the biochemistry of inherited metabolic diseases.[1] She investigated the structure of glycogen and amylopectins,[2][8] and defined the pathway and mechanisms of phosphorylase enzymes.[9][10] Her research included the discovery of enzymes[11] in a previously unknown pathway to process glycogen.[12] She went on to research diseases related to the storage of glycogen where these enzymes were absent.[13][14] She applied some of Carl Cori's findings to medical cases,[15] and confirmed the second known case of fructose bisphosphatase deficiency, a rare metabolic disorder, in 1970.[16][17] She played a similar role in therapeutic research into glycogen storage disease type I.[18][19]
Personal life
editHer husband, David H. Brown, was also a scientist and they collaborated on research on polysaccharide synthesis and glycogen storage diseases.[2]
Selected publications
edit- ILLINGWORTH, BARBARA A; RUSSELL, JANE A (1951). "The Effects of Growth Hormone on Glycogen in Tissues of the Rat1". Endocrinology. 48 (4): 423–434. doi:10.1210/endo-48-4-423. ISSN 0013-7227. OCLC 4631825308. PMID 14831545.
- Illingworth, Barbara; Jansz, Hendrik S.; Brown, David H.; Cori, Carl F. (1958-12-15). "Observations on the Function of Pyridoxal-5-Phosphate in Phosphorylase". Proceedings of the National Academy of Sciences. 44 (12): 1180–1191. Bibcode:1958PNAS...44.1180I. doi:10.1073/pnas.44.12.1180. ISSN 0027-8424. PMC 528705. PMID 16590330.
- Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1961-04-01). "The De Novo Synthesis of Polysaccharide by Phosphorylase". Proceedings of the National Academy of Sciences. 47 (4): 469–478. Bibcode:1961PNAS...47..469I. doi:10.1073/pnas.47.4.469. ISSN 0027-8424. PMC 221475. PMID 13717528.
- Eberlein, Walter R; Illingworth, Barbara A; Sidbury, James B (1962). "Heterogeneous glycogen storage disease in siblings and favorable response to synthetic androgen administration". AJM the American Journal of Medicine. 33 (1): 20–26. doi:10.1016/0002-9343(62)90273-5. ISSN 0002-9343. OCLC 4922525423. PMID 13889017.
- Brown, Barbara Illingworth; Brown, David H (1966). "Lack of an α -1,4-Glucan: α -1,4-Glucan 6-glycosyl Transferase in a Case of Type IV Glycogenosis". Proceedings of the National Academy of Sciences of the United States of America. 56 (2): 725–729. Bibcode:1966PNAS...56..725B. doi:10.1073/pnas.56.2.725. ISSN 0027-8424. OCLC 5554094258. PMC 224432. PMID 5229990.
References
edit- ^ a b c "Brown, Barbara "Bobbie" (Illingworth)". madison.com. October 1, 2016.
- ^ a b c d e f g Exton, John H. (2013). "Contributions of Barbara and David Brown". Crucible of science : the story of the Cori laboratory. New York: Oxford University Press. pp. 161–164. ISBN 978-0-19-986108-8. OCLC 843881801.
- ^ Illingworth, Barbara A (1950). Effects of purified growth hormone on glycogen storage. New Haven. OCLC 42655887.
{{cite book}}: CS1 maint: location missing publisher (link) - ^ "Wilbur Cross Medalists by Department" (PDF). Yale Graduate School of Arts and Sciences. Archived from the original (PDF) on 2021-04-14. Retrieved 2021-02-13.
- ^ "Washington University School of Medicine Bulletin". 1967.
{{cite journal}}: Cite journal requires|journal=(help) - ^ "Dr. Brown Appointed to Council" (PDF). The NIH Record. 24 (4): 8. February 15, 1972.
- ^ "List of Past Wilbur Cross Recipients | Yale Graduate School of Arts & Sciences". gsas.yale.edu.
- ^ Illingworth, Barbara; Larner, Joseph; Cori, Gerty T. (1952-12-01). "Structure of Glycogens and Amylopectins: I. Enzymatic Determination of Chain Length*". Journal of Biological Chemistry. 199 (2): 631–640. doi:10.1016/S0021-9258(18)38501-6. ISSN 0021-9258. PMID 13022670.
- ^ Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1961-04-01). "The De Novo Synthesis of Polysaccharide by Phosphorylase". Proceedings of the National Academy of Sciences. 47 (4): 469–478. Bibcode:1961PNAS...47..469I. doi:10.1073/pnas.47.4.469. ISSN 0027-8424. PMC 221475. PMID 13717528.
- ^ Illingworth, Barbara; Jansz, Hendrik S.; Brown, David H.; Cori, Carl F. (1958-12-15). "Observations on the Function of Pyridoxal-5-Phosphate in Phosphorylase". Proceedings of the National Academy of Sciences. 44 (12): 1180–1191. Bibcode:1958PNAS...44.1180I. doi:10.1073/pnas.44.12.1180. ISSN 0027-8424. PMC 528705. PMID 16590330.
- ^ Brown, David H.; Illingworth, Barbara (1962-10-01). "The Properties of an Oligo-1,4 → 1,4-Glucantransferase from Animal Tissues". Proceedings of the National Academy of Sciences. 48 (10): 1783–1787. Bibcode:1962PNAS...48.1783B. doi:10.1073/pnas.48.10.1783. ISSN 0027-8424. PMC 221040. PMID 14015933.
- ^ Brown, David H.; Illingworth, Barbara; Cori, Carl F. (1963). "Enzymatic Debranching of Glycogen: Combined Action of Oligo-1,4→1,4-glucan-transferase and Amylo-1,6-glucosidase in Debranching Glycogen". Nature. 197 (4871): 980–982. Bibcode:1963Natur.197..980B. doi:10.1038/197980a0. ISSN 1476-4687. PMID 14015932. S2CID 4161911.
- ^ Hauk, Rosalind; Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1959-06-01). "Enzymes of glycogen synthesis in glycogen-deposition disease". Biochimica et Biophysica Acta. 33 (2): 554–556. doi:10.1016/0006-3002(59)90149-0. ISSN 0006-3002. PMID 13670930.
- ^ Illingworth, Barbara; Kornfeld, Rosalind; Brown, David H. (1960). "Phosphorylase and uridinediphosphoglucose-glycogen transferase in pyridoxine deficiency". Biochimica et Biophysica Acta. 42: 486–489. doi:10.1016/0006-3002(60)90827-1. PMID 13717529.
- ^ Correspondence with Carl Cori, David and Barbara Brown Papers, Collection FC179, Becker Archives, Washington University School of Medicine.
- ^ Brockhoff, Dorothy (Spring 1971). "Her Present Is Her Health". Outlook Magazine. 8 (2): 16–18.
- ^ Pagliara, Anthony S.; Karl, Irene E.; Keating, James P.; Brown, Barbara I.; Kipnis, David M. (1 August 1972). "Hepatic fructose-1,6-diphosphatase deficiency: A cause of lactic acidosis and hypoglycemia in infancy". The Journal of Clinical Investigation. 51 (8): 2115–2123. doi:10.1172/JCI107018. ISSN 0021-9738. PMC 292368. PMID 4341015.
- ^ Malatack, J. Jeffrey; Finegold, David N.; Iwatsuki, Shunzaburo; Shaw, Byers W.; Gartner, J. Carlton; Zitelli, Basil J.; Roe, Thomas; Starzl, Thomas E. (14 May 1983). "Liver Transplantation for Type I Glycogen Storage Disease". Lancet. 1 (8333): 1073–1075. doi:10.1016/s0140-6736(83)91910-4. ISSN 0140-6736. PMC 3022514. PMID 6133106.
- ^ Starzl, T E; Putnam, C W; Porter, K A; Halgrimson, C G; Corman, J; Brown, B I; Gotlin, R W; Rodgerson, D O; Greene, H L (October 1973). "Portal diversion for the treatment of glycogen storage disease in humans". Annals of Surgery. 178 (4): 525–539. doi:10.1097/00000658-197310000-00015. ISSN 0003-4932. PMC 1355694. PMID 4517839.