Avetisyan (Armenian: Ավետիսյան) is an Armenian surname. Notable people with the surname include:
- Arsen Avetisyan (born 1973), an Armenian football player
- Andranik Avetisyan (born 1968), Armenian artist
- Erdzhanik Avetisyan (born 1969), an Armenian and Russian sport shooter
- Goar Avetisyan (born 1993), a famous russian make-up artist and internet personality
- Hunan Avetisyan (1913–1943), a Soviet senior sergeant awarded the title Hero of the Soviet Union
- Khachatur Avetisyan (1926–1996), an Armenian-Soviet composer
- Minas Avetisyan (1928–1975), an Armenian painter
- Varduhi Avetisyan (born 1986), an Armenian swimmer