Avermitilol synthase (EC 4.2.3.96) is an enzyme with systematic name avermitilol hydrolase (cyclizing, avermitilol-forming).[1] This enzyme catalyses the following chemical reaction
| Avermitilol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.96 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnesyl diphosphate + H2O avermitilol + diphosphate
This enzyme requires Mg2+.
References
edit- ^ Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE (July 2010). "Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol". Journal of the American Chemical Society. 132 (26): 8850–1. doi:10.1021/ja103087w. PMC 2904616. PMID 20536237.
External links
edit- Avermitilol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
