Aspoxicillin

Aspoxicillin
Clinical data
Trade names	Doyle
Other names	TA-058
Identifiers
	IUPAC name (2S,5R,6R)-6-[[(2R)-2-[[(2R)-2-Amino-4-(methylamino)-4-oxobutanoyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;
CAS Number	63358-49-6;
PubChem CID	71961;
DrugBank	DB13816;
UNII	0745KNO26J;
CompTox Dashboard (EPA)	DTXSID6046921 ;
ECHA InfoCard	100.162.655
Chemical and physical data
Formula	C21H27N5O7S
Molar mass	493.54 g·mol−1

Aspoxicillin (trade name Doyle^[1]) is an antibiotic drug of the beta-lactam class.^[2] It is an injectable form of penicillin that is highly active against Gram-positive and Gram-negative bacteria, including Bacillus fragilis,^[3] which is resistant to other beta-lactam antibiotics.^[4] It is approved for use in Japan.^[1]

References

^ ^a ^b "Aspoxicillin". IUPHAR/BPS Guide to Pharmacology.
^ Matsumoto K (July 1987). "[Review: New antimicrobial agent series XXII: Aspoxicillin]". The Japanese Journal of Antibiotics. 40 (7): 1221–1242. PMID 3316732.
^ "Aspoxicillin". Inxight Drugs. National Center for Advancing Translational Sciences.
^ Edwards R (December 1997). "Resistance to beta-lactam antibiotics in Bacteroides spp". Journal of Medical Microbiology. 46 (12): 979–986. doi:10.1099/00222615-46-12-979. PMID 9402919.

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[IUPHAR-1] "Aspoxicillin". IUPHAR/BPS Guide to Pharmacology.

[2] Matsumoto K (July 1987). "[Review: New antimicrobial agent series XXII: Aspoxicillin]". The Japanese Journal of Antibiotics. 40 (7): 1221–1242. PMID 3316732.

[3] "Aspoxicillin". Inxight Drugs. National Center for Advancing Translational Sciences.

[4] Edwards R (December 1997). "Resistance to beta-lactam antibiotics in Bacteroides spp". Journal of Medical Microbiology. 46 (12): 979–986. doi:10.1099/00222615-46-12-979. PMID 9402919.

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