Andrew Duncan may refer to:
- Andrew Duncan (minister, died 1626) (c. 1560–1626), Scottish minister
- Andrew Duncan (physician, born 1744) (1744–1828), Scottish pioneer for improved institutional care and treatment of mental health problems, founder of Royal Edinburgh Hospital
- Andrew Duncan (minister, born 1766) (1766–1827), Moderator of the Church of Scotland in 1824
- Andrew Duncan (physician, born 1773) (1773–1832), Scottish physician and professor at the University of Edinburgh
- Andrew Duncan (mayor) (1834–1880), third mayor of Christchurch, New Zealand
- Sir Andrew Duncan (businessman) (1882–1952), British businessman, MP and public official
- Andrew Duncan (poet) (born 1956), British poet
- Andrew Duncan (rugby league) (born 1972), British rugby league footballer
- Andrew Duncan (director), Canadian television director and writer
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