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Amit Singh is an Indian microbiologist and an associate professor at the Department of Microbiology and cell biology of the Indian Institute of Science. A Wellcome-DBT Senior Fellow, Singh is known for his studies on the pathogenesis of Mycobacterium tuberculosis. His research focuses on exploring the mechanisms behind the persistence of human pathogens like disease and HIV.
Amit Singh | |
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| Born | India |
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| Known for | Mycobacterium tuberculosis pathogenesis |
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The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development for 2017/18. He was awarded the Shanti Swarup Bhatnagar award in 2021 for his research. He received the 2021 Shanti Swarup Bhatnagar Prize for Science and Technology in Biological Science.[1]
Biography
editAmit Singh was born on 18 March 1976.[2] He graduated in science from the University of Delhi and earned his master's degree in biotechnology from the Indian Institute of Technology Roorkee in 1998.[3] He then obtained a Ph.D. in 2004 under the guidance of Anil Kumar Tyagi at the South Campus of the University of Delhi and moved to the US for post-doctoral training at the laboratory of Adrie JC Steyn of the University of Alabama in Birmingham.
On his return to India in 2010, he joined the International Centre for Genetic Engineering and Biotechnology as a Wellcome Trust-DBT intermediate fellow. In January 2014, he joined the Indian Institute of Science (IISc) at their department of microbiology and cell biology, where he holds the position of an associate professor.[4] He heads the Centre for Infectious Disease Research as its group leader,[5] hosting several researchers[6] who do research on the mechanisms of chronic human infections with a special focus on Mycobacterium tuberculosis and human immunodeficiency virus (HIV).[7][8]
Singh has been a Wellcome Trust-DBT senior fellow since 2016.[9][10] The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development for 2017/18.[11]
Publications
editMost cited articles at University of Alabama
edit- Singh, A; Crossman, DK; Mai, D; Guidry, L; Voskuil, MI; Renfrow, MB; Steyn, AJ (2009). "Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response". PLOS Pathog. 5 (8): e1000545. doi:10.1371/journal.ppat.1000545. PMC 2718811. PMID 19680450. (Cited by 204 articles according to Google Scholar.)
- Singh, A; Guidry, L; Narasimhulu, KV; Mai, D; Trombley, J; Redding, KE; Giles, GI; Lancaster, JR Jr; Steyn, AJ (2007). "Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival". Proc Natl Acad Sci U S A. 104 (28): 11562–7. Bibcode:2007PNAS..10411562S. doi:10.1073/pnas.0700490104. PMC 1906726. PMID 17609386. (Cited by 154 articles according to Google Scholar.)
Most cited articles at IISc
edit- Ashima Bhaskar, Manbeena Chawla, Mansi Mehta, Pankti Parikh, Pallavi Chandra, Devayani Bhave, Dhiraj Kumar, Kate S Carroll, Amit Singh. Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection. 2014. PLOS Pathogens. 10:1 e1003902. (Cited by 88 articles according to Google Scholar.)
- Rufai SB, Kumar P, Singh A, Prajapati S, Balooni V, Singh S. Comparison of Xpert MTB/RIF with line probe assay for detection of rifampin-monoresistant Mycobacterium tuberculosis. Journal of clinical microbiology. 2014 June; 52 (6): 1846–52. (Cited by 76 articles according to Google Scholar.)
- Chawla M, Parikh P, Saxena A, Munshi M, Mehta M, Mai D, Srivastava AK, Narasimhulu KV, Redding KE, Vashi N, Kumar D. Adrie JC Steyn and Amit Singh. Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. Molecular microbiology. 2012 September; 85 (6): 1148–65. (Cited by 56 articles according to Google Scholar.)
References
edit- ^ "Shanti Swarup Bhatnagar Prize (SSB) for Science and Technology 2021" (PDF). sbprize.gov.in. Council of Scientific and Industrial Research. Retrieved 26 September 2021.
- ^ "Scientist Amit Singh". Hindi Info World. 26 November 2021.
- ^ "Centre for Infectious Disease Research (CIDR)". cidr.iisc.ernet.in. 11 January 2019. Archived from the original on 12 January 2019. Retrieved 11 January 2019.
- ^ "MCB". mcbl.iisc.ac.in. 11 January 2019. Archived from the original on 13 January 2019. Retrieved 11 January 2019.
- ^ "Centre for Infectious Disease Research (CIDR) Group Leader". cidr.iisc.ernet.in. 11 January 2019. Archived from the original on 12 January 2019. Retrieved 11 January 2019.
- ^ "Centre for Infectious Disease Research (CIDR) fellows". cidr.iisc.ac.in. 11 January 2019. Archived from the original on 3 July 2018. Retrieved 11 January 2019.
- ^ "Welcome to lab web page of Dr. Amit Singh". cidr.iisc.ac.in. 11 January 2019. Archived from the original on 4 October 2018. Retrieved 11 January 2019.
- ^ Bhaskar, Ashima; Chawla, Manbeena; Mehta, Mansi; Parikh, Pankti; Chandra, Pallavi; Bhave, Devayani; Kumar, Dhiraj; Carroll, Kate; Singh, Amit (2014). "Reengineering Redox Sensitive GFP to Measure Mycothiol Redox Potential of Mycobacterium tuberculosis during Infection". PLOS Pathogens. 10 (1): e1003902. doi:10.1371/journal.ppat.1003902. PMC 3907381. PMID 24497832.
- ^ "India Alliance - About Fellow". www.indiaalliance.org. 11 January 2019. Retrieved 11 January 2019.
- ^ "Amit Singh Group, Indian Institute of Science, Bangalore -- Publication". Retrieved 8 May 2019.
- ^ "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Archived from the original (PDF) on 4 March 2018. Retrieved 20 November 2017.
Further reading
edit- Prasad, R. (29 September 2018). "IISc team finds new approaches to kill TB bacteria". The Hindu. Retrieved 11 January 2019.
- "How do TB bacteria develop resistance to common antibiotics? A new study at IISc attempts to answer this". Research Matters. 6 July 2017. Retrieved 11 January 2019.