Akkineni is an Indian surname that may refer to
- Akkineni Lakshmi Vara Prasada Rao, popularly known as L. V. Prasad was a famous Indian film actor, producer and director
- Akkineni Ramesh Prasad son of Akkineni Lakshmi Vara Prasada Rao
- Akkineni Sreekar Prasad, National award-winning film editor, grandson of L. V. Prasad
- Akkineni Kutumba Rao veteran filmmaker
- Akkineni Nageswara Rao, veteran Telugu film actor and producer
- Akkineni Nagarjuna, a popular Telugu film actor and producer; son of Akkineni Nageswara Rao
- Amala Akkineni, an actress; wife of Akkineni Nagarjuna
- Akkineni Naga Chaitanya, a Telugu film actor; son of Akkineni Nagarjuna and his ex-wife, Lakshmi Ramanaidu Daggubati
- Samantha Akkineni, Actress;Former wife of Akkineni Naga Chaitanya
- Akkineni Akhil, son of Akkineni Nagarjuna and Akkineni Amala