Acanthocystis turfacea chlorella virus 1 (ATCV-1), also called Chlorovirus ATCV-1 or Chlorella virus ATCV-1 is a species of giant double-stranded DNA virus in the genus Chlorovirus.
| Acanthocystis turfacea chlorella virus 1 | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Varidnaviria |
| Kingdom: | Bamfordvirae |
| Phylum: | Nucleocytoviricota |
| Class: | Megaviricetes |
| Order: | Algavirales |
| Family: | Phycodnaviridae |
| Genus: | Chlorovirus |
| Species: | Acanthocystis turfacea chlorella virus 1
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The host of ATCV-1 is Chlorella heliozoae; it was demonstrated that "ATCV-1 neither attaches to nor infects" Chlorella variabilis.[1][2]
Human infection
editDNA from ATCV-1 has been isolated from the mucous membranes of the noses of humans. In both humans and mice, the presence of ATCV-1 on the oropharyngeal mucosa was associated with lower scores in tests of cognitive and motor skills.[3][4][5] Injection of purified algal virus ATCV-1 intracranially results in long-lasting cognitive and behavioural effects in mice via induction of inflammatory factors.[6]
References
edit- ^ Irina Agarkova; Brigitte Hertel; Xinzheng Zhang; Les Lane; Alexander Tchourbanov; David D. Dunigan; Gerhard Thiel; Michael G. Rossmann; James L. Van Etten (2014). "Dynamic attachment of Chlorovirus PBCV-1 to Chlorella variabilis". Virology. 466–467: 95–102. doi:10.1016/j.virol.2014.07.002. PMC 4254200. PMID 25240455.
- ^ "SAG 211-6 Chlorella variabilis". EPSAG The Culture Collection of Algae at the University of Göttingen, Germany. Archived from the original on 2017-09-23. Retrieved 2017-09-23.
- ^ Yolken, R. H.; Jones-Brando, L.; Dunigan, D. D.; Kannan, G.; Dickerson, F.; Severance, E.; Sabunciyan, S.; Talbot, C. C.; Prandovszky, E.; Gurnon, J. R.; Agarkova, I. V.; Leister, F.; Gressitt, K. L.; Chen, O.; Deuber, B.; Ma, F.; Pletnikov, M. V.; Van Etten, J. L. (2014). "Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice". Proc Natl Acad Sci U S A. 111 (45): 16106–11. Bibcode:2014PNAS..11116106Y. doi:10.1073/pnas.1418895111. PMC 4234575. PMID 25349393.
- ^ Yolken; et al. (2015). "Reply to Kjartansdóttir et al.: Chlorovirus ATCV-1 findings not explained by contamination". Proceedings of the National Academy of Sciences. 112 (9): E927. Bibcode:2015PNAS..112E.927Y. doi:10.1073/pnas.1424665112. PMC 4352770. PMID 25654982.
- ^ Elizabeth Pennisi (27 October 2014), "Algal virus found in humans, slows brain activity", Science
- ^ Marilyn S. Petro; Irina V. Agarkova; Thomas M.Petro (May 2016). "Effect of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice". Journal of Neuroimmunology. 297: 46–55. doi:10.1016/j.jneuroim.2016.05.009. PMID 27397075. S2CID 38573451.
External links
edit- "Acanthocystis turfacea chlorella virus 1". NCBI Taxonomy Browser. 322019.
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