ANXA8L2

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.

ANXA8L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W3W,%%s1W45, 1W3W
Identifiers
Aliases	ANXA8L1, ANXA8, ANXA8L2, VAC-beta, bA145E20.2, annexin A8-like 1, annexin A8 like 1
External IDs	MGI: 1201374; HomoloGene: 20393; GeneCards: ANXA8L1; OMA:ANXA8L1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q11.22 Start 46,375,627 bp End 46,391,784 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 B|14 20.8 cM Start 33,807,938 bp End 33,822,528 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg mucosa of esophagus placenta right lung vagina olfactory zone of nasal mucosa upper lobe of left lung minor salivary glands testicle Top expressed in skin of external ear corneal stroma lip conjunctival fornix ankle ankle joint skin of back skin of abdomen decidua esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium-dependent phospholipid binding metal ion binding calcium ion binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding actin filament binding Cellular component extracellular exosome intracellular anatomical structure cytosol plasma membrane late endosome membrane collagen-containing extracellular matrix Biological process endosome organization endosomal transport negative regulation of serine-type endopeptidase activity negative regulation of phospholipase A2 activity hemostasis blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 728113 11752 Ensembl ENSG00000264230 ENSMUSG00000021950 UniProt Q5VT79 P13928 O35640 RefSeq (mRNA) NM_001039801 NM_001098845 NM_001278923 NM_001278924 NM_001630 NM_001281845 NM_013473 RefSeq (protein) NP_001092315 NP_001265852 NP_001265853 NP_001035173 NP_001258631 NP_001258632 NP_001268774 NP_038501 Location (UCSC) Chr 10: 46.38 – 46.39 Mb Chr 14: 33.81 – 33.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.

External links

• Human ANXA8 genome location and ANXA8 gene details page in the UCSC Genome Browser.
• Human ANXA8L1 genome location and ANXA8L1 gene details page in the UCSC Genome Browser.

Further reading

• Gerke V, Moss SE (2002). "Annexins: from structure to function". Physiol. Rev. 82 (2): 331–71. doi:10.1152/physrev.00030.2001. PMID 11917092.
• Gerke V, Creutz CE, Moss SE (2005). "Annexins: linking Ca2+ signaling to membrane dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 449–61. doi:10.1038/nrm1661. PMID 15928709. S2CID 37526262.
• Chang KS, Wang G, Freireich EJ, et al. (1992). "Specific expression of the annexin VIII gene in acute promyelocytic leukemia". Blood. 79 (7): 1802–10. doi:10.1182/blood.V79.7.1802.1802. PMID 1313714.
• Chambers JA, Gardner E, Hauptmann R, et al. (1993). "TaqI polymorphisms at the annexin VIII locus (ANX8)". Hum. Mol. Genet. 1 (7): 550. doi:10.1093/hmg/1.7.550. PMID 1364010.
• Hauptmann R, Maurer-Fogy I, Krystek E, et al. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". Eur. J. Biochem. 185 (1): 63–71. doi:10.1111/j.1432-1033.1989.tb15082.x. PMID 2530088.
• Sarkar A, Yang P, Fan YH, et al. (1994). "Regulation of the expression of annexin VIII in acute promyelocytic leukemia". Blood. 84 (1): 279–86. doi:10.1182/blood.V84.1.279.279. PMID 8018923.
• Reutelingsperger CP, van Heerde W, Hauptmann R, et al. (1994). "Differential tissue expression of Annexin VIII in human". FEBS Lett. 349 (1): 120–4. Bibcode:1994FEBSL.349..120R. doi:10.1016/0014-5793(94)00559-1. PMID 8045287. S2CID 8928858.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stein T, Price KN, Morris JS, et al. (2006). "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer". Clin. Cancer Res. 11 (19 Pt 1): 6872–9. doi:10.1158/1078-0432.CCR-05-0547. PMID 16203777.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Goebeler V, Ruhe D, Gerke V, Rescher U (2006). "Annexin A8 displays unique phospholipid and F-actin binding properties". FEBS Lett. 580 (10): 2430–4. Bibcode:2006FEBSL.580.2430G. doi:10.1016/j.febslet.2006.03.076. PMID 16638567. S2CID 22336528.