ADCY7

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.

ADCY7
Identifiers
Aliases	ADCY7, AC7, adenylate cyclase 7
External IDs	OMIM: 600385; MGI: 102891; HomoloGene: 866; GeneCards: ADCY7; OMA:ADCY7 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q12.1 Start 50,246,137 bp End 50,318,135 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 C3|8 43.06 cM Start 88,999,031 bp End 89,056,590 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood appendix secondary oocyte lymph node bone marrow cells spleen skin of hip gallbladder Top expressed in ascending aorta aortic valve tunica media of zone of aorta mesenteric lymph nodes Paneth cell carotid body blood fetal liver hematopoietic progenitor cell substantia nigra Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function adenylate cyclase activity ATP binding phosphorus-oxygen lyase activity metal ion binding nucleotide binding lyase activity guanylate cyclase activity Cellular component integral component of membrane membrane plasma membrane guanylate cyclase complex, soluble intracellular anatomical structure integral component of plasma membrane Biological process renal water homeostasis intracellular signal transduction cellular response to ethanol cellular response to glucagon stimulus cyclic nucleotide biosynthetic process maternal process involved in female pregnancy cGMP biosynthetic process signal transduction adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cAMP biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of adaptive immune response cellular response to lithium ion negative regulation of cytokine production involved in inflammatory response activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113 11513 Ensembl ENSG00000121281 ENSMUSG00000031659 UniProt P51828 P51829 RefSeq (mRNA) NM_001114 NM_001286057 NM_001037723 NM_001037724 NM_001109756 NM_007406 RefSeq (protein) NP_001105 NP_001272986 NP_001032812 NP_001032813 NP_001103226 NP_031432 Location (UCSC) Chr 16: 50.25 – 50.32 Mb Chr 8: 89 – 89.06 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a membrane-bound adenylyl cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.

External links

• Human ADCY7 genome location and ADCY7 gene details page in the UCSC Genome Browser.

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Hellevuo K, Welborn R, Menninger JA, Tabakoff B (1997). "Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism". Am. J. Med. Genet. 74 (1): 95–8. doi:10.1002/(SICI)1096-8628(19970221)74:1<95::AID-AJMG19>3.0.CO;2-M. PMID 9034014.
• Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566. S2CID 7620262.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185. S2CID 22105709.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302. S2CID 24053412.
• Yan SZ, Tang WJ (2002). "Construction of Soluble Adenylyl Cyclase from Human Membrane-Bound Type 7 Adenylyl Cyclase". G Protein Pathways - Part C, Effector Mechanisms. Methods in Enzymology. Vol. 345. pp. 231–41. doi:10.1016/S0076-6879(02)45019-7. ISBN 978-0-12-182246-0. PMID 11665607.
• Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B (2003). "Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta". J. Biol. Chem. 278 (7): 4552–60. doi:10.1074/jbc.M210386200. PMID 12454008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609. S2CID 36697419.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beeler JA, Yan SZ, Bykov S, et al. (2005). "A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase". Biochemistry. 43 (49): 15463–71. CiteSeerX 10.1.1.558.7519. doi:10.1021/bi049088+. PMID 15581358.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hines LM, Hoffman PL, Bhave S, et al. (2006). "A sex-specific role of type VII adenylyl cyclase in depression". J. Neurosci. 26 (48): 12609–19. doi:10.1523/JNEUROSCI.1040-06.2006. PMC 6674903. PMID 17135423.