In enzymology, a 5-aminovalerate transaminase (EC 2.6.1.48) is an enzyme that catalyzes the chemical reaction
5-aminovalerate transaminase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 2.6.1.48 | ||||||||
CAS no. | 37277-97-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
- 5-aminopentanoate + 2-oxoglutarate 5-oxopentanoate + L-glutamate
Thus, the two substrates of this enzyme are 5-aminopentanoate and 2-oxoglutarate, whereas its two products are 5-oxopentanoate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 5-aminopentanoate:2-oxoglutarate aminotransferase. Other names in common use include 5-aminovalerate aminotransferase, delta-aminovalerate aminotransferase, and delta-aminovalerate transaminase. This enzyme participates in lysine degradation. It employs one cofactor, pyridoxal phosphate.
References
edit- Ichihara A, Ichihara EA, Suda M (1960). "Metabolism of L-lysine by bacterial enzymes. IV. delta-Aminovaleric acid-glutamic acid transaminase". J. Biochem. 48 (3). Tokyo: 412–420.