The enzyme 4-hydroxyphenylacetate decarboxylase (EC 4.1.1.83) catalyzes the chemical reaction
| 4-hydroxyphenylacetate decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.1.1.83 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- (4-hydroxyphenyl)acetate + H+ 4-methylphenol + CO2
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming). Other names in common use include p-hydroxyphenylacetate decarboxylase, p-Hpd, 4-Hpd, and 4-hydroxyphenylacetate carboxy-lyase.
References
edit- D'Ari L, Barker HA (1985). "p-Cresol formation by cell-free extracts of Clostridium difficile". Arch. Microbiol. 143 (3): 311–2. doi:10.1007/BF00411256. PMID 3938267.
- Selmer T, Andrei PI (2001). "p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol". Eur. J. Biochem. 268 (5): 1363–72. doi:10.1046/j.1432-1327.2001.02001.x. PMID 11231288.
- Andrei PI, Pierik AJ, Zauner S, Andrei-Selmer LC, Selmer T (2004). "Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity". Eur. J. Biochem. 271 (11): 2225–30. doi:10.1111/j.1432-1033.2004.04152.x. PMID 15153112.
