3-Methyl-GABA, also known as HMS3266K11, is an anticonvulsant alkaloid.
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IUPAC name
4-Amino-3-methylbutanoic acid
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Other names
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3D model (JSmol)
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PubChem CID
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Properties | |
C5H11NO2 | |
Molar mass | 117.148 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pharmacology
edit3-Methyl-GABA is an activator of GABA-T, an enzyme that transforms GABA to succinate semialdehyde and glutamate.[1]
It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.[2][3]
References
edit- ^ "3-Methyl-GABA". Tocris Bioscience.
- ^ "3-Methyl-GABA". TargetMol.
- ^ Silverman RB, Andruszkiewicz R, Nanavati SM, Taylor CP, Vartanian MG (July 1991). "3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.