The 2021 French moratorium on prion research was a three-month moratorium on research on prions in France. The moratorium was announced in July 2021 by several public research institutions after a retired lab worker was diagnosed with Variant Creutzfeldt–Jakob disease and came two years after the death of Émilie Jaumain from the same disease after acquiring it in a lab accident.[1][2]
2010 incident
editIn May 2010, Émilie Jaumain, a 24 year-old scientist working in the virology and molecular immunology unit of the French National Institute of Agricultural Research (Institut national de la recherche agronomique, INRAE) in Jouy-en-Josas, accidentally pricked her thumb on a pair of forceps while cleaning a cryostat which stored the frozen brains of transgenic mice that overexpressed human prion protein. Despite wearing a double pair of latex gloves, the forceps cut her skin.[3]
In 2017, Jaumain began experiencing a number of neurological symptoms. In early 2019, she was diagnosed with Variant Creutzfeldt–Jakob disease, caused by prions. Three months after her diagnosis and less than a decade after the accident, she died. A 2020 paper in the New England Journal of Medicine that reviewed her case found that "percutaneous exposure to prion-contaminated material is plausible in this patient" and that there was a "need for improvements in the prevention of transmission of variant CJD and other prions that can affect humans in the laboratory and neurosurgery settings."[4]
After her death, Jaumain's family announced that they would be suing INRAE for negligence and manslaughter. The lawsuit alleged that she had not received proper training for handling prions, that she had not been supplied with cut-resistant gloves, and that there was a delay of twenty minutes for her to receive decontamination care for her injury.[5] A 2020 government inspection on safety conditions in prion research in France found that labs in France conformed to safety regulations, but that there was room to improve. The report further found that at least 17 lab accidents had been recorded in the last decade, of which five involved researchers being cut with contaminated blades and at least one of which occurred in the same lab where Jaumain worked in 2005 (although the researcher has not developed any symptoms).[6] A number of labs across France introduced more stringent safety rules after Jaumain's diagnosis, including switching to plastic scalpels.[7]
In April 2020, the Association EMILYS was founded to lobby for better health and safety regulations in research.[8] In June 2021, INRAE chair Philippe Mauguin wrote a letter to the Association EMILYS stating that "we recognize, without ambiguity, the hypothesis of a correlation between Emilie Jaumain-Houel's accident… and her infection with vCJD."[9]
2021 moratorium
editIn July 2021, it was announced that a second lab worker in France had been diagnosed with Creutzfeldt–Jakob disease.[10] In response, five public research institutions in France announced a three-month moratorium on prion research. The statement, backed by the French government, was signed by Inserm, INRAE, French National Centre for Scientific Research, French Alternative Energies and Atomic Energy Commission, and the Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail.[11]
See also
editReferences
edit- ^ Pascariello, Pascale (2021-08-01). "Creutzfeldt-Jakob : l'Inrae freine l'expertise judiciaire sur le décès d'une de ses laborantines". Mediapart (in French).
- ^ "Les laboratoires publics français suspendent leurs travaux sur les prions en raison d'une suspicion de cas de maladie de Creutzfeldt-Jakob". Le Monde. July 27, 2021.
- ^ "Une jeune chercheuse de l'Inra meurt après avoir contracté la maladie de la vache folle". TF1 INFO (in French). 2019-06-26. Retrieved 2023-09-25.
- ^ Brandel, Jean-Philippe; Vlaicu, M. Bustuchina; Culeux, Audrey; Belondrade, Maxime; Bougard, Daisy; Grznarova, Katarina; Denouel, Angeline; Plu, Isabelle; Bouaziz-Amar, Elodie; Seilhean, Danielle; Levasseur, Michèle; Haïk, Stéphane (2 July 2020). "Variant Creutzfeldt–Jakob Disease Diagnosed 7.5 Years after Occupational Exposure". New England Journal of Medicine. 383 (1): 83–85. doi:10.1056/NEJMc2000687. PMID 32609989.
- ^ "Une chercheuse de l'INRA meurt après avoir contracté la maladie de Creutzfeldt-Jakob". BFMTV.
- ^ "Sécurité dans les laboratoires de recherche sur les prions infectieux". Ministère de l'Education Nationale de la Jeunesse et des Sports.
- ^ "Pourquoi les labos français stoppent leurs recherches sur les mystérieux prions ?". www.vice.com. 6 August 2021.
- ^ "Association Emilys". Association Emilys (in French). Retrieved 2021-10-18.
- ^ Casassus, Barbara (28 July 2021). "France issues moratorium on prion research after fatal brain disease strikes two lab workers". Science. doi:10.1126/science.abl6587.
- ^ "A Second Person in France May Have Caught Deadly Prion Disease From Lab Exposure". Gizmodo. 28 July 2021.
- ^ "Suspension provisoire des travaux sur les prions dans les laboratoires de recherche publics français". INRAE Institutionnel.