The 16 winners of the second stage advanced to the round of 16.
Starting from the round of 16, the teams were seeded according to the second stage draw, with each team assigned a "seed" 1–16 corresponding to the tie they won (O1–O16) (Regulations Article 22.c).[ 2]
Starting from the round of 16, the teams played a single-elimination tournament with the following rules:[ 2]
In the round of 16, quarter-finals, and semi-finals, each tie was played on a home-and-away two-legged basis, with the higher-seeded team hosting the second leg (Regulations Article 22.d). If tied on aggregate, the away goals rule was used. If still tied, extra time was not played, and a penalty shoot-out was used to determine the winner (Regulations Article 27).
The final was played as a single match at a venue pre-selected by CONMEBOL, with the higher-seeded team designated as the "home" team for administrative purposes (Regulations Article 25). If tied after regulation, 30 minutes of extra time were played. If still tied after extra time, a penalty shoot-out was used to determine the winner (Regulations Article 28).
The bracket starting from the round of 16 was determined as follows:
Round
Matchups
Round of 16
(Higher-seeded team host second leg)
Match A: Winner O1 vs. Winner O16
Match B: Winner O2 vs. Winner O15
Match C: Winner O3 vs. Winner O14
Match D: Winner O4 vs. Winner O13
Match E: Winner O5 vs. Winner O12
Match F: Winner O6 vs. Winner O11
Match G: Winner O7 vs. Winner O10
Match H: Winner O8 vs. Winner O9
Quarter-finals
(Higher-seeded team host second leg)
Match S1: Winner A vs. Winner H
Match S2: Winner B vs. Winner G
Match S3: Winner C vs. Winner F
Match S4: Winner D vs. Winner E
Semi-finals
(Higher-seeded team host second leg)
Match F1: Winner S1 vs. Winner S4
Match F2: Winner S2 vs. Winner S3
Finals
(Higher-seeded team designated as "home" team)
The bracket was decided based on the second stage draw, which was held on 13 May 2019.
The first legs were played on 9–11 and 23–25 July, and the second legs were played on 16–18, 30–31 July and 1 August 2019.[ 4] [ 5]
La Equidad won 4–2 on aggregate and advanced to the quarter-finals (Match S1 ).
Independiente del Valle won 2–0 on aggregate and advanced to the quarter-finals (Match S2 ).
Fluminense won 5–2 on aggregate and advanced to the quarter-finals (Match S3 ).
Tied 3–3 on aggregate, Zulia won on away goals and advanced to the quarter-finals (Match S4 ).
Tied 1–1 on aggregate, Colón won on penalties and advanced to the quarter-finals (Match S4 ).
Corinthians won 4–1 on aggregate and advanced to the quarter-finals (Match S3 ).
Tied 3–3 on aggregate, Independiente won on away goals and advanced to the quarter-finals (Match S2 ).
Atlético Mineiro won 3–0 on aggregate and advanced to the quarter-finals (Match S1 ).
The first legs were played on 6, 8, 20 and 22 August, and the second legs were played on 13, 15, 27 and 29 August 2019.[ 6] [ 7]
Atlético Mineiro won 5–2 on aggregate and advanced to the semi-finals (Match F1 ).
Tied 2–2 on aggregate, Independiente del Valle won on away goals and advanced to the semi-finals (Match F2 ).
Tied 1–1 on aggregate, Corinthians won on away goals and advanced to the semi-finals (Match F2 ).
Colón won 4–1 on aggregate and advanced to the semi-finals (Match F1 ).
The first legs were played on 18–19 September, and the second legs were played on 25–26 September 2019.[ 8] [ 9]
Tied 3–3 on aggregate, Colón won on away goals and advanced to the final .
Independiente del Valle won 4–2 on aggregate and advanced to the final .
^ a b La Equidad played their home matches at Estadio El Campín , Bogotá , instead of their regular stadium Estadio Metropolitano de Techo , Bogotá .
^ a b c Independiente del Valle played their home matches at Estadio Olímpico Atahualpa , Quito , instead of their regular stadium Estadio Rumiñahui , Sangolquí .
^ Sporting Cristal played their home match at Estadio Alejandro Villanueva , Lima , instead of their regular stadium Estadio Alberto Gallardo , Lima .
^ Montevideo Wanderers played their home match at Estadio Gran Parque Central , Montevideo , instead of their regular stadium Parque Alfredo Víctor Viera , Montevideo .
^ Atlético Mineiro played their home match against Colón at Estádio Mineirão , Belo Horizonte , instead of their regular stadium Estádio Independência , Belo Horizonte .