In the first quarter, Matt Eller kicked a 51-yard field goal. Brit Miller recovered Michael Desormeaux's fumble for a 27-yard touchdown. Drew Edmiston kicked a 24-yard field goal for Louisiana-Lafayette.
Juice Williams passed to Daniel Dufrene for a 10-yard touchdown in the 2nd quarter.
In the second half, Desormeaux rushed for a 34-yard touchdown and passed to Erick Jones for an 11-yard touchdown. Matt Eller kicked a 27-yard field goal for the Fighting Illini.
The Illini lost on the road to the Nittany Lions 38–24 in a nationally televised, prime time, "White Out" game at Beaver Stadium. Illinois jumped out to a 14–7 lead, becoming the first team to take a lead on the Nittany Lions and the first to score points against them in the first quarter this season. However, the Nittany Lions responded with two touchdowns en route to a 21–14 halftime lead. The Illini wouldn't score again until kicking a field goal on the final play of the third quarter after recovering a Stephfon Green fumble, but Derrick Williams returned the ensuing kickoff for a touchdown.
The loss was head coach Ron Zook’s first as a head coach against a ranked opponent. The Illini's 24 points were the most allowed by Penn State this season as were their 189 total rushing yards.[10]
Penn State wide receiver Derrick Williams became the first player under PSU head coach Joe Paterno to score a rushing, a receiving, and a kick return touchdown in the same game.[10][11] Williams was selected the Big Ten Special Teams Player of the Week.[12]