2-Bromomescaline (2-Br-M) is a derivative of the phenethylamine hallucinogen mescaline which has an unusual 2-bromo substitution.[1][2] It is an agonist for serotonin receptors, with a binding affinity of 215 nM at 5-HT1A, 513 nM at 5-HT2A and 379 nM at 5-HT2C, so while it is around ten times more tightly binding than mescaline at 5-HT1A and 5-HT2A receptors, it is over twenty times more potent at 5-HT2C.[3] It has been reported as a designer drug, first identified in Austria in January 2023.[4]
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| Formula | C11H16BrNO3 |
| Molar mass | 290.157 g·mol−1 |
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See also
editReferences
edit- ^ Shulgin A, Manning T, Daley PF (2011). The Shulgin Index. Volume 1. Psychedelic Phenethylamines and Related Compounds. Transform Press. pp. 280–281, 355. ISBN 978-0-9630096-3-0.
- ^ Pecherer B, Sunbury RC, Brossi A (June 1972). "A novel synthesis of aromatic methoxy and methylenedioxy substituted 2,3,4,5-tetrahydro-1H3-benzazepines". Journal of Heterocyclic Chemistry. 9 (3): 609–616. doi:10.1002/jhet.5570090322.
- ^ Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. pp. 908–910. ISBN 978-3-03788-700-4.
- ^ "New psychoactive substances - the current situation in Europe" (PDF). European Drug Report. European Union Drugs Agency (EUDA). 2024.
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