2,000 Guineas may refer to the following horse races:
- 2000 Guineas Stakes, in England in May since 1807
- 2,000 Guineas Trial Stakes, in England in April 1968–1986
- Irish 2,000 Guineas
- New Zealand 2000 Guineas
- UAE 2000 Guineas
- French 2,000 Guineas, unofficial nickname for the Poule d'Essai des Poulains